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痰涂阳性肺结核患者密切接触者结核菌感染情况调查

, PP. 684-686

Keywords: γ,干扰素,酶联免疫斑点,结核菌素皮肤试验,结核菌感染

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Abstract:

目的应用早期建立的结核分枝杆菌特异性IFN-γ酶联免疫斑点(Elispot)检测技术,以及结核菌素皮肤试验评价痰涂阳性肺结核患者密切接触者中结核菌的感染情况。方法采用Elispot技术检测1242例痰涂阳性肺结核患者的密切接触者进行外周血结核菌特异性IFN-γ水平,同时平行进行PPD皮试。结果Elispot在密切接触者以及接触者中家属,朋友的阳性率分别是30%,34.25%和22.1%,PPD相应的结果是13.2%,15.57%和8.9%;两者阳性率比较差异有统计学意义(P结论与PPD比较利用Elispot诊断结核潜伏感染有较高辅助诊断价值。利用Elispot监测结核密切接触者,有利于早期发现结核病人。

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