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国产注射用缓释醋酸亮丙瑞林治疗中枢性性早熟疗效观察

, PP. 872-874

Keywords: 注射用缓释醋酸亮丙瑞林,中枢性性早熟,疗效

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Abstract:

目的分析国产注射用缓释醋酸亮丙瑞林治疗中枢性性早熟的临床疗效。方法分析20例中枢性性早熟的女性患儿经国产注射用缓释醋酸亮丙瑞林治疗12月前后的身高、性征变化、内生殖器(卵巢)变化、黄体生成素(LuteinizingHormone,LH)峰值变化及骨龄增长情况。结果20例患儿治疗后生长速率(GV)均有下降,治疗前、治疗后3月、6月、12月分别为(8.6±1.6)cm/年、(7.15±1.3)cm/年、(5.9±1.1)cm/年、(5.2±1.8)cm/年,各组间差异有统计学意义;所有患儿治疗后3~6月乳房明显回缩,B超提示卵巢体积逐渐缩小,卵泡缩小或消失,治疗12月卵巢体积均骨龄/Δ生活年龄=0.57,预测身高增加(3.8±1.6)cm。结论国产注射用缓释醋酸亮丙瑞林能抑制中枢性性早熟患儿性征发育及骨龄进展,达到增加性早熟患儿成年身高的目的,与同类进口药品相比,具有同样的效果。因其价格相对低,具有较大的经济学价值,对经济条件相对差的西部地区中枢性性早熟患儿的治疗更为适用。

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