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利奈唑胺体外诱导粪肠球菌中介耐药及机制研究

, PP. 797-799

Keywords: 粪肠球菌,利奈唑胺,体外诱导,耐药,中介,变异

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Abstract:

目的研究利奈唑胺对粪肠球菌中介耐药的体外诱导作用并探讨其耐药机制。方法采用多步诱导法对4株临床分离粪肠球菌以及质控菌株进行体外诱导耐药试验,采用琼脂平皿二倍稀释法测定诱导前后的MIC值,采用PCR测序法检测粪肠球菌4个23SrRNAV区基因的变异。结果4株临床分离粪肠球菌和质控菌株均诱导出中介株和稳定耐药株,在中介株和耐药株中均检测到了G2576U、G2505A和C2424U变异,2株中介株和耐药株还同时存在G2576U和C2424U变异。结论利奈唑胺可体外诱导粪肠球菌产生中介株和稳定性耐药株,粪肠球菌中介株即可出现23SrRNAV区基因变异。

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