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卵巢上皮性癌中ZEB1的表达及其临床意义

, PP. 863-865

Keywords: 上皮性卵巢癌,上皮间质化,ZEB1,免疫组化

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Abstract:

目的探讨ZEB1在人卵巢原发性上皮性癌中的表达及其临床意义。方法选取广州军区武汉总医院2006~2010年间手术切除并经病理证实的人正常卵巢组织12例,卵巢原发性上皮性癌60例,其中FIGOI期20例,II期18例,III期17例,IV期5例,应用免疫组织化学法检测卵巢上皮性癌组织中ZEB1蛋白的表达,分析其与卵巢癌患者临床病理特征的关系。结果ZEB1蛋白在正常卵巢中不表达,在49例(81.67%)卵巢癌中为阳性表达。ZEB1蛋白在各期卵巢上皮性癌中的阳性率分别为I-II期73.68%(28/38),III-IV期95.45%(21/22),差异有统计学意义(PPP=0.002)。结论ZEB1在卵巢上皮性癌的发生发展中起重要的作用,可能是卵巢癌治疗的潜在靶点。

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