全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

海南地区地中海贫血基因分型及频率的研究

, PP. 804-806

Keywords: 地中海贫血,基因分型,基因频率

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨海南地区地中海贫血基因突变的类型和频率。方法采用聚合酶链反应(PCR)、琼脂糖凝胶电泳和反向斑点杂交(RDB)技术进行地中海贫血基因分型的检测。结果在2000例受检者中,α阳性率为35.95%,常见亚型为-SEA/αα;β阳性率为25.80%,常见亚型为β41-42/βA。结论海南地区地中海贫血发生率较高,做好婚前及产前地中海贫血基因诊断等工作,对避免地中海贫血患儿的出生,提高当地人口素质具有重要意义。

References

[1]  (林樟萍,吴洁,覃西.海南黎族孕妇α-地中海贫血和缺铁性贫血发生率及常用血液学参数分析[J].现代预防医学,2011,38(13):2467-2470.)
[2]  Zhou DF,Wang Z,Wang XY,et al.Study on sistypes of -thalassemia mutation in Han and Linationality of Hainan province[J].J Hainan Medical College,2007,13(1):5-7.(In Chinese)
[3]  (周代锋,王政,王小英,等.海南省汉、黎族人群中6种β-地中海贫血基因突变的研究[J] .海南医学院学报,2007,13(1): 5-7.)
[4]  Liu XL,Wang J,Yang C,et al.Analysis of the gene type and the prevalence of thalassemia in Hai kou area[J].Chin J Birth Health & Heredity,2012,20(9):22-23.(In Chinese)
[5]  (刘秀莲,王洁,杨春,等.海口地区地中海贫血基因分型及频率的研究[J].中国优生与遗传杂志,2012,20(9):22-23. )
[6]  Wang GY, Yao HX, Lin LE. Observation on the effect of partial splenic artery embolization on 12 thalassemia cases[J]. China Trop Med, 2013,13(1):121-122.(In Chinese)
[7]  (王谷云,姚红霞,林丽娥.部分脾动脉栓塞治疗地中海贫血12例疗效观察[J].中国热带医学,2013,13(1):121-122.)
[8]  Wang HL,Guo H,Xiong LK.Progress in researches of α -thalassanemia[J]. China Trop Med,2011,11(9):1158-1160. (In Chinese)
[9]  (王辉林,郭华,熊礼宽.α-地中海贫血研究进展[J]. 中国热带医学,2011,11(9):1158-1160.)
[10]  Liu XL,Wang J, Zhao ZD, et al.Study on Genotypes in 89 Patients of α-thalassemia in Haikou Area[J]. Life Science Research, 2012,16(5):420-422. (In Chinese)
[11]  (刘秀莲,王洁,赵振东,等.海口地区89例地中海贫血基因型的研究[J]. 生命科学研究,2012,16(5):420-422. )
[12]  Zhou DF,Wang A,Cai LJ,et al.Investigation into the deletion types of α-thalassemia in Han and LI nationalities in Hainan province[J].China Trop Med,2006,6(9):1549-1551. (In Chinese)
[13]  (周代锋,王政,蔡兰洁,等.海南省汉、黎族人群缺失型α-地中海贫血的研究[J].中国热带医学,2006,6(9):1549-1551.)
[14]  Lin ZP,Wu J,Qin X.The incidence of α-thalassemia and iron deficiency anemia of Hainan Li pregnant women and analysis of the commonly used hematological parameters [J].Modem Prev Med,2011,38(13):2467-2470. (In Chinese)
[15]  Zhang ZN.Standard of diagnosis and curative effect of blood disease[M]. Tianjin:Tianjin Science and Technology Press,1991.45-46. (In Chinese)
[16]  (张之南主编.血液病诊断及疗效标准[M].天津:天津科学技术出版社,1991.45-46.)
[17]  Wee YC,Tan KL,Kuldip K,et a1.Alpha-thalassaemia in assoaiation with beta-thalassaemia patients in Malaysia:a study on the co-inheritance of both disorders[J].Community Genet,2008,11:129-134.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133