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甘草醇沉淀物有效部位对RSV作用的体外实验研究

, PP. 793-796

Keywords: 甘草,抗病毒,呼吸道合胞病毒,醇沉淀物

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Abstract:

目的比较甘草的醇沉淀物乙醇提取部位体外抗呼吸道合胞病毒(RSV)作用。方法采用薄层色谱法、Molish反应定性鉴定甘草乙醇提取部位;以利巴韦林为阳性对照药,采用细胞培养技术及四氮唑蓝(MTT)比色法,观察这些提取部位对Hela细胞的药物毒性作用及抑制RSV作用。结果HPD722-乙醇部位、HPD750-乙醇部位、D101-乙醇部位均不含甘草酸、黄酮类物质、甘草多糖;对RSV感染的治疗指数(TI=TC50/EC50)依次为123.93、3.13、5.35。结论甘草醇沉淀物中HPD722-乙醇部位在体外具有显著抑制RSV作用,可能是新的抗RSV有效部位。

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