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化学品皮肤毒性替代法研究进展

, PP. 1163-1166

Keywords: 化学品,皮肤毒性替代试验,研究进展

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Abstract:

传统的化学品安全性评价方法不仅需要大量的动物、耗时长、成本高,不能满足化合物快速增长的需要,而且存在敏感性不够,种属差异等缺点,特别是不符合动物保护和福利的要求。发展快速、高效、敏感的毒理学安全性评价替代方法是近几年国际发展趋势。本文拟就近年来在化学品皮肤毒性评价中的皮肤腐蚀性替代试验、皮肤刺激性替代试验、皮肤光毒性替代试验、皮肤过敏性替代试验方法研究概况进行综述。

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