全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

海南黎汉族人群中高血压与ACE基因多态性的研究

, PP. 1149-1150

Keywords: 血管紧张素转换酶,基因多态性,高血压,等位基因

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨海南黎族和汉族人群血管紧张素转换酶(ACE)基因多态性与高血压的关系。方法于2010年对三个市县筛选高血压者85例作为病例组,血压正常者119例作为对照组,黎族101例,汉族103例。应用多聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测ACE基因的插入/缺失(I/D)多态性。用χ2检验,比较不同组人群ACE基因I/D多态性基因型频率和I、D等位基因频率的差异。结果在黎族EH组ACE各基因型的分布频率为II型44.7%、ID型34.2%、DD型21.1%,D等位基因频数38.2%;黎族NT组为II54.0%、ID33.3%、DD12.7%,D等位基因频数29.4%;黎族两组I/D基因型和D等位基因频数分布差异均无统计学意义(P>0.05)。汉族EH组三种基因型比例分别是II53.2%、ID10.6%、DD36.2%,D等位基因频数28.7%,汉族NT组II57.1%、ID28.6%、DD14.3%,D等位基因频数28.6%。汉族两组I/D基因型和D等位基因频数分布差异均无统计学意义(P>0.05)。结论海南黎族和汉族地区人群ACE基因I/D多态性与原发性高血压的发生无关联。

References

[1]  Li M,Wang N, Ma LY.Relationship of ACE gene polymorphism with hypertension in Dongxiang and Yugu ethnic minorities[J].Journal of Clinical Cardiology, 2006, 22( 7) : 435- 437.(In Chinese)
[2]  (李梅, 王楠, 马丽雅. 甘肃省独有少数民族原发性高血压患者与血管紧张素转化酶基因变异的关系[ J] . 临床心血管病杂志, 2006, 22( 7) : 435- 437.)
[3]  Liu ZR. Nearly a decade in hypertension prevalence rate[J]. Prevention and Treatment of Cardio-cerebral-vascular Disease, 2003, 3(6) : 52~ 53.(In Chnese)
[4]  (刘忠仁. 近十年我国高血压患病率概括.[J] . 心脑血管病防治杂志, 2003, 3(6) : 52-53.)
[5]  Fu Y, Qi Q, et al. Epidemiological survey of hypertension incidence and risk factors in Hainan Province[J].China Tropical Medicine, 2005,5(9),1959-1960.(In Chinese)
[6]  (符艳, 齐全,等. 海南省高血压及其危险因素流行病学调查[ J] .热带医学杂志, 2005,5(9);1959-1960.)
[7]  Mo rise T, Takeuch i Y, Takeda R. Angiotensis converting enzyme polymorph ism and essential hypertension[J]. Lancet,1994,343:125
[8]  Duru K, Farrow S, Wang JM , et al. Frequency of a deletion polymorphism in the gene for angiotensin covering enzyme is increased in African Americans with hypertension[J]. A m J Hyper tens,1994:757-759
[9]  Yun ML, Zhong JH, Jin SJ,et al. Study on the relationship between ACE gene polymorphismsand risk factors in hypertension patients of LI Nationality and Han Nationality in Hainan Province[J].China Tropical Medicine, 2007,7(7):1084-1086.(In Chinese)
[10]  (云美玲, 钟江华, 金水晶,等. 海南黎汉族高血压人群ACE 基因多态性与危险因素研究[J]. 热带医学杂志,2007,7(7):1084-1086.)
[11]  Yang YX, Kong XD, Lv HB, et al. Polymorphism of angiotensinogen gene and angiotensin-coverting enzyme gene in essential hypertension [J]. Henan Medical Research, 2002,11(6):109-110.(In Chinese)
[12]  (杨宇霞,孔祥东,吕宏宝,等. 原发性高血压与血管紧张素转换酶基因及血管紧张素原基因多态性[J]. 河南医学研究,2002,11(6):109-110.)

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133