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松油烯-4-醇对人宫颈癌HeLa细胞增殖活性的影响

, PP. 1048-1050

Keywords: 松油烯-4-醇,HeLa细胞,细胞增殖

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Abstract:

目的分析天然成分松油烯-4-醇对人宫颈癌HeLa细胞增殖活性的影响。方法体外培养人宫颈癌细胞HeLa,经不同浓度(0.001%~0.010%)松油烯-4-醇作用24h后,倒置显微镜观察细胞形态变化,四甲基偶氮唑蓝(MTT)比色法检测细胞活性。结果细胞形态明显改变,可见显著凋亡的特征;在药物浓度为0.001%~0.006%时,随着浓度增加,抑制率从14.0%上升至95.1%,松油烯-4-醇对HeLa细胞的抑制作用明显增强;在药物浓度为0.006%~0.01%时,抑制率维持在95.1%~96.3%,抑制作用未见增强。结论天然成分松油烯-4-醇对人宫颈癌HeLa细胞增殖有明显的抑制作用。

References

[1]  Valdespino VM,Valdespino VE. Cervical cancer screening: state of the art[J]. Curr Opin Obstet Gynecol,2006,18(1): 35-40.
[2]  Wang N. Results of screening of cervical cancer in rural women in Hainan Province in 2010[J].China Trop Med,2011,11(8):1038. (In Chinese)
[3]  (王宁. 2010 年海南省农村妇女宫颈癌普查结果分析[J].中国热带医学,2011,11(8):1038.)
[4]  Oliva B,Piccirilli E,Ceddia T,et al. Antimycotic activity of Melaleuca alternifolia and its major components[J].Lett Appl Microbiol,2003,37(2):185-187.
[5]  Hayes AJ,Leach DN,Markham JL, et a1.In vitro cytotoxieity of Amtralian tea tree oil using human cell lines[J].J Essent Oil Res, 1997,9(5):575-582.
[6]  Guo YW,Wei XQ,Li YW,et a1.Effects of shikoni on the proliferation of hepatoce llular carcinoma cells[J].China Trop Med,2008,8(8):1302-1304. (In Chinese)
[7]  (郭云蔚,尉秀清,李永伟,等. 紫草素对肝癌细胞增殖的影响[J]. 中国热带医学,2008,8(8):1302-1304.)
[8]  Hou C,Pan XK,Chen C,et a1.Effects of tetramethylpyrazine on human cervical carcinoma cell line HeLa and its mechanisms[J].New Med,2013,44(1):61-64. (In Chinese)
[9]  (侯常,潘雪珂,陈朝,等. 川芎嗪对人宫颈癌HeLa 细胞增殖的影响及其分子机制[J]. 新医学,2013,44(1),61-64.)
[10]  Zhang W,Li Y,Lv SJ,et a1.Effect of juglone at different concentrations on HeLa cells[J].Shanghai J Tradit Chin Med,2012,46(6):101-103. (In Chinese)
[11]  (张巍,李妍,吕士杰,等. 不同浓度的胡桃醌对宫颈癌HeLa 细胞的细胞毒作用研究[J]. 上海中医药杂志,2012,46(6):101-103.)
[12]  Ren DD,Chen G. Inhibition Effect of Okra Polysaccharides on Proliferation of Human Cancer Cell Lines[J].Food Sci,2010,31(21):353-356. (In Chinese)
[13]  (任丹丹,陈谷. 黄秋葵多糖组分对人体肿瘤细胞增殖的抑制作用[J].食品科学,2010,31(21 ):353-356.)
[14]  Wu PC,Zhang W. Research progress on tea tree oil[J].China pharmaceuticals,2009,18(3):61-63. (In Chinese)
[15]  (吴鹏昌,张伟. 茶树油的研究进展[J]. 中国药业,2009,18(3):61-63.)
[16]  Calcabrini A, Stringaro A, Toccacieli L, et al. Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells[J]. J Invest Dermatol, 2004,122(2):349-360.
[17]  Giordani C, Molinari A, Toccacieli L, et al. Interaction of tea tree oil with model and cellular membranes[J]. J Med Chem,2006,49(15):4581-4588.

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