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尿微量白蛋白与对比剂肾病发生的相关性

, PP. 443-445

Keywords: 尿微量白蛋白,肾小球滤过率,对比剂肾病,冠状动脉介入治疗

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Abstract:

目的研究尿微量白蛋白与对比剂肾病发生的相关性,以期预测对比剂肾病的发生。方法选择2013年3月至2013年10月在海南省人民医院心内科择期行冠状动脉介入诊疗的患者339例,对所有受试者入院时(即术前)测血压、血脂、血糖、C反应蛋白、尿微量白蛋白及基础尿素氮、肌酐值,计算肾小球滤过率|并分别于术后24h、48h、72h测患者血肌酐值。根据对比剂肾病发生与否分为A组(对比剂肾病组)32例和B组(非对比剂肾病组)307例。并记录患者在术中所用的对比剂的剂量。结果339例患者中有32例发生对比剂肾病,发生率为9.43%,A组患者的术前尿微量白蛋白,C反应蛋白、尿素氮及纤维蛋白原均高于B组,肾小球滤过率则低于B组。Logisitic多因素回归分析显示,尿微量白蛋白是对比剂肾病发生的独立危险因素。结论尿微量白蛋白是对比剂肾病的发生的独立危险因素,术前测定尿微量白蛋白对于预测对比剂肾病的发生,提前预防对比剂肾病有重要的意义。

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