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孤立性纤维性肿瘤的临床病理研究

, PP. 915-918

Keywords: 孤立性纤维性肿瘤,病理特征,免疫组织化学

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Abstract:

目的探讨孤立性纤维性肿瘤(SFT)的临床及病理形态特征、诊断和鉴别诊断。方法收集发生于不同部位的18例SFT患者,进行临床、组织学形态和免疫组化染色观察,并复习相关文献。结果SFT患者临床主要表现为缓慢生长的肿块,全身各个解剖部位皆可发生,发病高峰在40~70岁。镜下由交替分布的细胞丰富区和细胞稀疏区组成,被纤维性间质分隔,胶原纤维丰富,并具有血管外皮瘤样分支状血管。免疫组化瘤细胞特征性强阳性表达CD34和Bcl-2,Vimentin和CD99也呈阳性表达,不表达CK、S-100和SMA。但是,CD34和Bcl-2并不总是阳性,尤其是在恶性SFT患者。若CD34阴性,Bcl-2一般呈弥漫强阳性表达。结论SFT是一种在形态学和免疫表型上比较有特征性的肿瘤,需要与其它梭形细胞肿瘤相鉴别。大部分病例完整切除可以治愈,但需要长期随访。

References

[1]  Chan JK. Solitary fibrous tumour—everywhere, and a diagnosis in vogue[J]. Histopathology,1997,31:568–576.
[2]  Morimitsu Y, Nakajima M, Hisaoka M, et al. Extrapleural solitary fibrous tumor: clinicopathologic study of 17 cases and molecular analysis of the p53 pathway[J]. APMIS,2000,108:617–625.
[3]  Guillou L, Fletcher JA, Fletcher CDM, et al. Extrapleural solitary fibrous tumor and haemangiopericytoma. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours–Pathology and Genetics of Tumours of Soft Tissue and Bone[M]. Lyon, France: IARC Press,2002:86–90.
[4]  Guangning Zhao, Gang Li, Farui Fa. Solitary Fibrous Tumor of the Kidney with Massive Retroperitoneal Recurrence. A Case Presentation[J]. ONCOLOGY LETTERS,2012,4: 993-995.
[5]  Youcai Zhu, Kaiqi Du, et al. Solitary fibrous tumors of pleura and lung: report of twelve cases[J]. Journal of Thoracic Disease,2013,5:310-313.
[6]  Birte Schulz, Annelore Altendorf-Hofmann, et al. Loss of CD34 and high IGF2 are associated with malignant transformation in solitary fibrous tumors[J]. Pathology-Research and Practice,2014,210: 92- 97.
[7]  Nagarjun Rao, MD, FRCPath, et al. Intrapulmonary Solitary Fibrous Tumors Clinicopathologic and Immunohistochemical Study of 24 Cases[J]. Surg Pathol,2013,37:155-166.
[8]  Koichiro Watanabe, Satoshi Otsu, et al. CD34-negative solitary fibrous tumour resistant to imatinib[J]. BMJ Case Rep,2013:1-3.
[9]  Robinson LA. Solitary fibrous tumor of the pleura[J]. Cancer Control,2006,13:264-269.
[10]  王坚,朱雄增. 软组织肿瘤病理学[M]. 北京:人民卫生出版社,2008.2.1
[11]  Brunnemann RB, Ro JY, Ordonez NG, et al. Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases[J]. Mod Pathol,1999,12:1034-1042.
[12]  Cardillo G, Facciolo F, Cavazzana AO, et al. Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients[J]. Ann Thorac Surg,2000,70:1808-1812.

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