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基底细胞样乳腺癌组织Apaf-1蛋白表达临床意义

, PP. 1096-1098

Keywords: 乳腺肿瘤,基底细胞样乳腺癌,凋亡蛋白酶活化因子

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Abstract:

目的检测凋亡蛋白酶活化因子(Apaf-1)在基底细胞样乳腺癌(BLBC)中的表达,分析Apaf-1与BLBC临床病理特征的关系。方法采用免疫组化方法检测43例BLBC、57例non-BLBC和60例癌旁正常乳腺组织中Apaf-1蛋白的表达。结果免疫组化检测结果显示,在BLBC及non-BLBC中Apaf-1的表达的阳性率分别为23.26%和49.12%,明显低于癌旁正常乳腺组织的75.00%,差异均有统计学意义(PP<0.05)。结论BLBC组织低表达Apaf-1,Apaf-1可能与BLBC的发生、发展密切相关。

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