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抗耶氏肺孢子菌合成抗原IgG和IgM及IgA抗体水平调查

, PP. 1347-1350

Keywords: 耶氏肺孢子菌,主要表面糖蛋白,重组抗原,抗体

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Abstract:

目的利用北京地区随机人群,抗耶氏肺孢子菌(Pneumocystisjirovecii,Pj)人工合成主要表面糖蛋白(Recombinantmajorsurfaceglycoprotein),调查抗PjrMsg、IgG、IgM和IgA抗体水平,探讨人群感染Pj情况。方法利用原核表达的PjrMsg可溶抗原,建立酶联免疫吸附试验,调查266例北京地区随机人群血清抗PjrMsgIgG、IgM和IgA抗体的检出情况。结果北京地区266例随机血清,抗PjrMsgIgG、IgM和IgA抗体检出率分别为42.5%(113/266),41.7%(111/266)和0(0/266)。其中同期IgG阳性IgM阳性、IgG阳性IgM阴性、IgG阴性IgM阳性和IgG阴性IgM阴性的检出率分别为17.3%(46/266)、25.2%(67/266)、24.4%(65/266)和33.1%(88/266)。40~50岁组的抗PjrMsgIgM抗体检出率为62.8%(59/94),分别高于20~29岁组的32.9%(28/85)(χ2=15.895,P=0.000)和30~39岁组的27.6%(24/87)(χ2=22.522,P=0.000)。结论北京地区成人抗PjrMsgIgG与IgM抗体阳性率分别为42.5%和41.7%,人群感染Pj后的IgG或IgM抗体阳性率高达66.9%,IgA抗体没有检出以及IgM抗体在高年龄组中检出率高的原因需要进一步研究。

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