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非清髓造血干细胞移植治疗重型再生障碍性贫血

, PP. 1517-1519

Keywords: 非清髓,造血干细胞移植,再生障碍性贫血

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Abstract:

目的探讨非清髓造血干细胞移植治疗重型再生障碍性贫血(Severealpasticanemia,SAA)的方法及疗效。方法对5例确诊的SAA患者进行了全相合的造血干细胞移植(Hematopoieticstemcelltransplantation,HSCT),预处理方案为环磷酰胺(Cyclophosphamide,CY)+氟达拉滨(Fludarabine,FLU)+抗人胸腺球蛋白(Antithymocyteglobulin,ATG)。观察采用该方案的非清髓预处理后患者造血重建时间及疗效。结果5例患者移植后第10~14d供者造血重建,第30d行患者骨髓人类短串联重复序列复合扩增(Shorttadomrepeated-PCR,STR-PCR)检测显示为完全供者的基因型。其中1例出现I度急性移植物抗宿主病(Acutegraft-versus-hostdisease,aGVHD),2例口腔黏膜感染,1例肺部感染,随访至移植后3~28个月,造血功能恢复良好。结论以CY+FLU+ATG的非清髓性预处理方案造血干细胞移植治疗SAA,能够获得稳定的植入,且并发症少,是有效移植方法。

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