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自然杀伤T细胞细胞与乙型病毒性肝炎的关联性

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Keywords: 病毒性肝炎,乙型,自然杀伤T细胞

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Abstract:

自然杀伤T细胞(NaturalKillerTCell,NKT)指具有固有免疫应答功能的特殊的T细胞。当肝细胞上出现乙肝病毒(HBV)时,CD1d(clusterofdifferentiation1d,CD1d)能将鞘磷脂α-半乳糖酰基鞘氨醇(α-GalCer)提呈给NKT细胞上的T细胞受体(TCellReceptor,TCR)而将其活化,活化后的NKT细胞能够分泌IL-4、IFN-γ,参与免疫反应。最近的研究发现,微粒体甘油三酯转运蛋白(MicrosomalTriglycerideTransferProtein,MTP)能够影响CD1d的提呈功能。除此之外,有研究从分子通路PD1/PDL1方面进一步阐述了NKT与乙型病毒型肝炎的关系。本文回顾近年NKT细胞与乙型病毒性肝炎相关文章发现,NKT细胞与机体乙肝病毒清除有重要联系。

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