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miRNA分子在肺结核患者单核细胞中的表达及意义

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Keywords: 肺结核,单核细胞,微小RNA,实时探针定量PCR

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Abstract:

目的分析肺结核患者(TB)外周血单核细胞中miR-34a-5p和miR-708-5p的表达水平,并探讨其临床诊断价值。方法选取TB患者和健康对照(HD)各25例,应用TaqManqPCR技术测定两组人群外周血单核细胞中miR-34a-5p和miR-708-5p表达水平,以U6snRNA作为内参。应用ROC曲线评价miR-34a-5p和miR-708-5p诊断TB的临床意义。结果miR-34a-5p在TB患者中的表达水平为(10.08±0.68),显著高于HD的(7.67±0.36),差异有统计学意义(PP结论miR-34a-5p和miR-708-5p分子在TB患者外周血单核细胞中异常表达,对TB辅助诊断具有一定参考价值。

References

[1]  World Health Organization (WHO),Global Tuberculosis Report[OL],2014. Available:
[2]  Wang C,Yang S,Sun G,et al. Comparative miRNA expression profiles in individuals with latent and active tuberculosis [J]. PLoS One,2011,6(10):e25832.
[3]  Maertzdorf J,Weiner J 3rd,Mollenkopf HJ,et al. Common patterns and disease-related signatures in tuberculosis and sarcoidosis [J]. Proc Natl Acad Sci U S A,2012,109(20):7853-7858.
[4]  张立群,孙照刚,高孟秋,等. 肺结核患者外周血单核细胞中差异表达miRNA的筛选[J]. 中国防痨杂志,2011,33(11):729-733.
[5]  Fu Y,Yi Z,Wu X,et al. Circulating microRNAs in patients with active pulmonary tuberculosis [J]. J Clin Microbiol,2011,49(12):4246-4251.
[6]  中华医学会. 临床诊疗指南 结核病分册[S]. 北京:人民卫生出版社,2005:7-9.
[7]  Ma F,Xu S,Liu X,et al. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ [J]. Nat Immunol,2011, 12(9):861-869.
[8]  Xiao B,Liu Z,Li BS,et al. Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response [J]. J Infect Dis,2009,200(6):916-925.
[9]  Rathod SS,Rani SB,Khan M,et al. Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways [J]. FEBS Open Bio,2014,4:485-495.
[10]  Guo P,Lan J,Ge J,et al. miR-708 acts as a tumor suppressor in human glioblastoma cells [J]. Oncol Rep,2013,30(2):870-876.

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