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MCM-41/PAA的制备及释药性能

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Abstract:

采用微波辅助法合成介孔分子筛(mesoporousmolecularsieve)MCM-41,将其与丙烯酸(acrylicacid,AA)经原位聚合,制备具有pH敏感性的新型复合材料MCM-41/聚丙烯酸(polyacrylicacid,PAA)。通过X射线衍射、Fourier红外分析、热重分析、N2吸附/脱附等表征材料的结构和性能,证明合成了一种新型高分子复合材料。以抗压利尿药物氢氯噻嗪为模型药物,通过液体紫外法研究复合材料的载药性能及其在人工胃液(pH=1.2)和人工肠液(pH=6.8)条件下的释药性能。结果显示MCM-41/PAA的载药量达51.75%,在人工胃液和人工肠液的体外模拟释药过程中显示出良好的pH控释的敏感性。这种材料可以用于肠道靶向控释领域。

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