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负载药物替莫唑胺的纳米羟基磷灰石/聚乳酸–羟基乙酸共聚物微球的缓释行为

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Abstract:

以聚乳酸–羟基乙酸共聚物(PLGA)和纳米羟基磷灰石(nHA)作为生物降解材料制备了药物替莫唑胺(Temozolomide,TMZ)的缓释系统。采用湿法化学工艺制备了球状和棒状的nHA粉末。将TMZ药物分子负载在nHA表面(nHA-TMZ),再通过乳化溶剂挥发法将nHA-TMZ包裹在PLGA微球中,同时研究了微球中nHA的形貌和含量对缓释微球物化性能的影响。用扫描电镜、紫外分光光度计分别测定了微球的结构、形貌、药物包封率和缓释行为。相比于不含有nHA的TMZ/PLGA缓释微球,nHA的介入能够显著提高药物的包封率,并且包封率与nHA的加入量有关。此外,药物释放实验表明包裹在微球中的nHA的形貌和溶解速率能够影响微球的缓释行为。

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