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硅酸盐学报 2013

多孔纳米二氧化硅球的制备及其对胰岛素的担载和释放行为

崔媛,李艳辉,段潜

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Abstract:

利用实心的二氧化硅纳米微球为原材料，通过用聚乙烯吡咯烷酮进行表面保护，用氢氧化钠对硅球进行溶蚀，制备多孔纳米二氧化硅微球。通过热重分析、扫描电镜及透射电镜对溶蚀的硅球进行表征。结果表明溶蚀前后，二氧化硅球的外形没有发生实质的变化，但在内部形成了多孔通道。用这种多孔状的纳米硅球对胰岛素进行担载和释放试验发现，经过多孔化处理后，硅球对胰岛素的担载能力增强，释放速率降低，说明经过溶蚀获得的纳米二氧化硅可以作为一种药物的微胶囊载体，在药物控制释放领域有一定的应用前景。

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