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HAp/mSiO2载药颗粒的制备及体外药物释放行为

DOI: 10.7521/j.issn.0454-5648.2014.04.08

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Abstract:

以缓慢混合钙和磷前驱物溶液的化学沉淀法制备类球形羟基磷灰石(HAp)颗粒,通过正交实验法以高的吸附药物分子(亚甲基蓝)数量及低的标准偏差为依据确定溶胶--凝胶工艺的最优条件,在疏硅醇性的HAp颗粒表面均匀沉积介孔二氧化硅(mSiO2)壳层,制备得到具有核壳结构的HAp/mSiO2颗粒,在0.10g/L的亚甲基蓝溶液中吸附量高达79.26mg/g,标准偏差为4.42。亚甲基蓝分子在颗粒上的吸附行为属于第II型吸附等温线,即分子以单体和二聚体的形式吸附在孔内。在磷缓冲液(pH=7.2~7.4)和Lysosome-like缓冲液(pH=4.7)中药物分子自载药颗粒中的释放行为有明显的pH值敏感性能,这与溶液离子对载药颗粒结构和药物分子与载体间的作用机制的影响有关。

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