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环境化学  2015 

DOI:10.7524/j.issn.0254-6108.2014.09.018

Keywords: 饮用水,药品和个人护理品,自动固相萃取,液相色谱-串联质谱

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Abstract:

建立了同时检测饮用水中6大类共12种典型药品和个人护理品（Pharmaceuticalsandpersonalcareproducts，PPCPs）的自动固相萃取-液相色谱-电喷雾三重四极杆串联质谱（ASPE-HPLC——ESI-MS/MS）方法.样品经ASPE（自动固相萃取）富集提取后，40℃氮吹至近干，用甲醇-水溶液（2080，V/V）定容至1mL后测定.采用正离子和负离子多反应监测离子模式（MRM）定性分析，针对不同扫描模式优化流动相条件，两次进样分析.在低、中、高的3个添加水平下，12种PPCPs的方法回收率为60.8%—110%，相对标准偏差为2.0%—14.0%；检出限（LOD）为0.02—1.5ng·L-1，定量限（LOQ）为0.06—5ng·L-1.应用该方法调查了北京市饮用水中PPCPs污染状况，结果表明，9种PPCPs（氧氟沙星、脱水红霉素、磺胺甲恶唑、卡马西平、舒必利、普萘洛尔、萘普生、苯扎贝特和双酚A）在不同饮用水水样中被检出，最高浓度为苯扎贝特34.47ng·L-1.该方法操作简单、灵敏度高、选择性强，符合饮用水样品中痕量污染物检测要求.

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