OALib Journal期刊
四种常见纳米材料对骨代谢的影响
Keywords: 纳米材料 ,骨代谢 ,生物力学
Abstract:
探讨4种常见纳米材料(单壁碳纳米管,多壁碳纳米管,纳米银,量子点)对小鼠骨代谢的影响.选取8周龄健康昆明小鼠给予不同剂量的上述4种纳米材料,各纳米材料分别设高、中、低剂量组,溶剂对照、离子对照组,以及阳性对照组,每周3次进行腹腔注射.用药6周后检测骨破坏情况、骨生物力学改变以及血清中钙的含量.结果显示,4种纳米材料与其相应溶剂对照组相比,多壁碳纳米管溶骨发生率显著增高,高、中剂量组骨灰干重比及3个剂量组生物力学指标有显著性差异,高剂量组血清钙显著升高;单壁碳纳米管溶骨发生率上升,高、中剂量组骨灰干重比及生物力学指标降低,各组血清钙水平无显著性差异;量子点各剂量组溶骨发生率无差异,高、中剂量组骨灰干重比、最大载荷、弹性载荷降低,血清钙水平无显著性差异;纳米银各剂量组溶骨发生率未增加,灰干重比、生物力学各指标及血清钙水平无统计学差异.多壁碳纳米管长期暴露可引起小鼠溶骨性破坏、骨量下降、骨强度减低;单壁碳纳米管与量子点对骨代谢的影响不显著,纳米银不会引起骨代谢改变.
References
[1] 唐学红, 肖先举. 纳米银的制备研究进展 [J]. 贵州化工, 2009, 12: 21-23 [2] Nygaard U C, Hansen J S, Samuelsen M, et al. Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice [J]. Toxicol Sci, 2009, 109: 113-123 [3] Chou C C, Hsiao H Y, Hong Q S, et al. Single-walled carbon nanotubes can induce pulmonary injury in mouse model [J]. Nano Lett, 2008, 8: 437-445 [4] Ji Z, Zhang D, Li L, et al. The hepatotoxicity of multi-walled carbon nanotubes in mice [J]. Nanotechnology,2009, 20: 445101 [5] 季雷华, 高素莲, 张斌. 量子点的合成、毒理学及其应用[J]. 环境化学, 2008,27(5):679-683 [6] 曲晨, 刘伟, 荣海钦,等. 纳米银的生物学特性及其潜在毒性的研究进展[J]. 环境与健康杂志,2010, 9:842-845 [7] Poland C A, Duffin R, Kinloch I, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study [J]. Nat Nanotechnol, 2008, 3: 423-428 [8] Hoshino A, Hanada S, Manabe N, et al. Immune response induced by fluorescent nanocrystal quantum dots in vitro and in vivo[J]. IEEE Trans Nanobioscience, 2009, 8: 51-57
Full-Text
Contact Us
service@oalib.com
QQ:3279437679
WhatsApp +8615387084133
