Paul R W, April M W, Alan M S, et al. Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics[J]. Toxicol Appl Pharm, 2010, 247: 18-27
[3]
Mariella Z, Lorena G, Franco Z, et al. Method for the quantification of underivatized amino acids on dry blood spots from newborn screening by HPLC-ESI-MS/MS[J]. J Chromatogr B, 2006, 31:267-273
[4]
Monique P, Christine V S, Konstantinos P, et al. ESI-MS/MS analysis of underivatised amino acids: a new tool for the diagnosis of inherited disorders of amino acid metabolism. Fragmentation study of 79 molecules of biological interest in positive and negative ionisation mode[J]. Rapid Commun Mass Spectrom, 2003, 17: 1297-1311
[5]
Jens N, Fozia N, Elmar H, et al. Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line HepG2[J].Toxicol Appl Pharm, 2009, 240: 327-336
[6]
Lake E Q, Stefanie D, Jens O K, et al. Metabolic flux analysis in mammalian cell culture [J]. Metab Eng, 2010, 12: 161-171
[7]
Gabriela G C, Jessica A Q, Alan M S, et al. Identification of small molecules from human embryonic stem gells using metabolomics[J]. Stem Cells Dev, 2007, 16: 869-882
[8]
Steffen K, J？rg S, Martin G. FluxAnalyzer: exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps [J]. Bioinformatics, 2003, 19(2): 261-269
[9]
Raymond Lo, Trine Celius, Agnes L Forgacs, et al. Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin[J]. Toxicol Appl Pharm, 2011, 257: 38-47
[10]
Forgacs Agnes L, Kent Michael N, Makley Meghan K, et al. Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver [J]. Toxicol Sci, 2012, 125: 41-45
[11]
Vidya V I, Hong Y, Marianthi G I, et al. Effects of glucose and insulin on HepG2-C3A cell metabolism[J]. Biotechnol Bioeng, 2010, 107: 347-356
Hestermann E V, Stegeman J J, Hahn M E. Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays[J]. Toxicol Sci, 2000, 53: 316-325
