Halling-S？rensen B, Nors Nielsen S, Lanzky P F, et al. Occurrence, fate and effects of pharmaceutical substances in the environment-A review[J]. Chemosphere, 1998, 36(2): 357-393
[2]
Martinez J L. Environmental pollution by antibiotics and by antibiotic resistance determinants[J]. Environmental Pollution, 2009, 157(11): 2893-2902
[3]
Hernando M, Mezcua M, Fernandezalba A, et al. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments[J]. Talanta, 2006, 69(2): 334-342
[4]
Moreno-Bondi M C, Marazuela M D, Herranz S, et al. An overview of sample preparation procedures for LC-MS multiclass antibiotic determination in environmental and food samples[J]. Analytical and Bioanalytical Chemistry, 2009, 395(4): 921-946
[5]
Richardson B, Lam P, Martin M. Emerging chemicals of concern: Pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China[J]. Marine Pollution Bulletin, 2005, 50(9): 913-920
[6]
Ben W W, Qiang Z M, Adams C, et al. Simultaneous determination of sulfonamides, tetracyclines and tiamulin in swine wastewater by solid-phase extraction and liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2008, 1202(2): 173-180
[7]
Abuin S, Codony R, Compano R, et al. Analysis of macrolide antibiotics in river water by solid-phase extraction and liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2006, 1114(1): 73-81
[8]
Vazquez-Roig P, Segarra R, Blasco C, et al. Determination of pharmaceuticals in soils and sediments by pressurized liquid extraction and liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography A, 2010, 1217(16): 2471-2483
[9]
Gobel A, Thomsen A, McArdell C, et al. Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge[J]. Journal of Chromatography A, 2005, 1085(2): 179-189
[10]
Lffler D, Ternes T A. Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography A, 2003, 1021(1/2): 133-144
[11]
Blackwell P A, Holten Lützh？ft H C, Ma H P, et al. Ultrasonic extraction of veterinary antibiotics from soils and pig slurry with SPE clean-up and LC-UV and fluorescence detection[J]. Talanta, 2004, 64(4): 1058-1064
[12]
Zhou J H, Xue X F, Li Y, et al. Multiresidue determination of tetracycline antibiotics in propolis by using HPLC-UV detection with ultrasonic-assisted extraction and two-step solid phase extraction[J]. Food Chemistry, 2009, 115(3): 1074-1080
[13]
Yang J F, Ying G G, Zhao J L, et al. Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC-MS/MS[J]. Science of the Total Environment, 2010, 408(16): 3424-3432
[14]
Leal C, Codony R, Compano R, et al. Determination of macrolide antibiotics by liquid chromatography[J]. Journal of Chromatography A, 2001, 910(2): 285-290
[15]
Ramirez A J, Mottaleb M A, Brooks B W, et al. Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry[J]. Analytical Chemistry, 2007, 79(8): 3155-3163
[16]
Wang L, Yang H, Zhang C W, et al. Determination of oxytetracycline, tetracycline and chloramphenicol antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography[J]. Analytica Chimica Acta, 2008, 619(1): 54-58
[17]
Schneider M J, Braden S E, Reyes-Herrera I, et al. Simultaneous determination of fluoroquinolones and tetracyclines in chicken muscle using HPLC with fluorescence detection[J]. Journal of Chromatography B, 2007, 846(1/2): 8-13
[18]
Mamani M C V, Reyes F G R, Rath S. Multiresidue determination of tetracyclines, sulphonamides and chloramphenicol in bovine milk using HPLC-DAD[J]. Food Chemistry, 2009, 117(3): 545-552
[19]
Horie M, Takegami H, Toya K, et al. Determination of macrolide antibiotics in meat and fish by liquid chromatography-electrospray mass spectrometry[J]. Analytica Chimica Acta, 2003, 492(1/2): 187-197
[20]
Renew JHuang C. Simultaneous determination of fluoroquinolone, sulfonamide, and trimethoprim antibiotics in wastewater using tandem solid phase extraction and liquid chromatography-electrospray mass spectrometry[J]. Journal of Chromatography A, 2004, 1042(1/2): 113-121
[21]
Tong L, Li P, Wang Y X, et al. Analysis of veterinary antibiotic residues in swine wastewater and environmental water samples using optimized SPE-LC/MS/MS[J]. Chemosphere, 2009, 74(8): 1090-1097
[22]
Lindberg R, Jarnheimer P A, Olsen B, et al. Determination of antibiotic substances in hospital sewage water using solid phase extraction and liquid chromatography/mass spectrometry and group analogue internal standards[J]. Chemosphere, 2004, 57(10): 1479-1488
[23]
Pailler J Y, Krein A, Pfister L, et al. Solid phase extraction coupled to liquid chromatography-tandem mass spectrometry analysis of sulfonamides, tetracyclines, analgesics and hormones in surface water and wastewater in Luxembourg[J]. Science of the Total Environment, 2009, 407(16): 4736-4743
[24]
Yang S, Cha J, Carlson K. Simultaneous extraction and analysis of 11 tetracycline and sulfonamide antibiotics in influent and effluent domestic wastewater by solid-phase extraction and liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Journal of Chromatography A, 2005, 1097(1/2): 40-53
[25]
Balakrishnan V K, Terry K A, Toito J. Determination of sulfonamide antibiotics in wastewater: A comparison of solid phase microextraction and solid phase extraction methods[J]. Journal of Chromatography A, 2006, 1131(1/2): 1-10
[26]
Franek M, Diblikova I, Cernoch I, et al. Broad-specificity immunoassays for sulfonamide detection: Immunochemical strategy for generic antibodies and competitors[J]. Analytical Chemistry, 2006, 78(5): 1559-1567
[27]
Peippo P, Hagren V, Lovgren T, et al. Rapid time-resolved fluoroimmunoassay for the screening of narasin and salinomycin residues in poultry and eggs[J]. Journal of Agricultural and Food Chemistry, 2004, 52(7): 1824-1828
[28]
Langin A, Alexy R, Konig A, et al. Deactivation and transformation products in biodegradability testing of beta-lactams amoxicillin and piperacillin[J]. Chemosphere, 2009, 75(3): 347-354
[29]
Lindberg R H, Wennberg P, Johansson M I, et al. Screening of human antibiotic substances and determination of weekly mass flows in five sewage treatment plants in sweden[J]. Environmental Science & Technology, 2005, 39(10): 3421-3429
[30]
Xu W H, Zhang G, Li X D, et al. Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China[J]. Water Research, 2007, 41(19): 4526-4534
[31]
Batt A L, Kim S, Aga D S. Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations[J]. Chemosphere, 2007, 68(3): 428-435
[32]
Zuccato E, Castiglioni S, Bagnati R, et al. Source, occurrence and fate of antibiotics in the Italian aquatic environment[J]. Journal of Hazardous Materials, 2010, 179(1/3): 1042-1048
[33]
Hijosa-Valsero M, Fink G, Schlüsener M P, et al. Removal of antibiotics from urban wastewater by constructed wetland optimization[J]. Chemosphere, 2011, 83(5): 713-719
[34]
Sim W J, Lee J W, Lee E S, et al. Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures[J]. Chemosphere, 2011, 82(2): 179-186
[35]
Gao L H, Shi Y L, Li W H, et al. Occurrence of antibiotics in eight sewage treatment plants in Beijing, China[J]. Chemosphere, 2012, 86(6): 665-671
[36]
Wei R C, Ge F, Huang S Y, et al. Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China[J]. Chemosphere, 2011, 82(10): 1408-1414
[37]
Duong H A, Pham N H, Nguyen H T, et al. Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam[J]. Chemosphere, 2008, 72(6): 968-973
[38]
Xu W H, Zhang G, Zou S C, et al. Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Environmental Pollution, 2007, 145(3): 672-679
[39]
Jiang L, Hu X, Yin D, et al. Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China[J]. Chemosphere, 2011, 82(6): 822-828
[40]
Wiegel S, Aulinger A, Brockmeyer R, et al. Pharmaceuticals in the river Elbe and its tributaries[J]. Chemosphere, 2004, 57(2): 107-126
[41]
Kolpin D W, Furlong E T, Meyer M T, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999—2000: A national reconnaissance[J]. Environmental Science & Technology, 2002, 36(6): 1202-1211
[42]
Calamari D, Zuccato E, Castiglioni S, et al. Strategic survey of therapeutic drugs in the rivers Po and Lambro in Northern Italy[J]. Environmental Science & Technology, 2003, 37(7): 1241-1248
[43]
Kim S CCarlson K. Temporal and spatial trends in the occurrence of human and veterinary antibiotics in aqueous and river sediment matrices[J]. Environmental Science & Technology, 2007, 41(1): 50-57
[44]
Xu W H, Zhang G, Zou S C, et al. A preliminary investigation on the occurrence and distribution of antibiotics in the Yellow River and its Tributaries, China[J]. Water Environment Research, 2009, 81(3): 248-254
[45]
Tamtam F, Mercier F, Le Bot B, et al. Occurrence and fate of antibiotics in the Seine River in various hydrological conditions[J]. Science of the Total Environment, 2008, 393(1): 84-95
[46]
Gao L H, Shi Y L, Li W H, et al. Occurrence, distribution and bioaccumulation of antibiotics in the Haihe River in China[J]. Journal of Environmental Monitoring, 2012, 14(4): 1248-1255
[47]
Lindsey M E, Meyer M, Thurman E M. Analysis of trace levels of sulfonamide and tetracycline antimicrobials, in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry[J]. Analytical Chemistry, 2001, 73(19): 4640-4646
[48]
Hirsch R, Ternes T, Haberer K, et al. Occurrence of antibiotics in the aquatic environment[J]. Science of the Total Environment, 1999, 225(1/2): 109-118
[49]
Holm J V, Rugge K, Bjerg P L, et al. Occurrence and distribution of pharmaceutical organic-compounds in the groundwater downgradient of a landfill (grindsted, denmark)[J]. Environmental Science & Technology, 1995, 29(5): 1415-1420
[50]
Zuccato E, Calamari D, Natangelo M, et al. Presence of therapeutic drugs in the environment[J]. Lancet, 2000, 355(9217): 1789-1790
[51]
Benotti M J, Trenholm R A, Vanderford B J, et al. Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water[J]. Environmental Science & Technology, 2009, 43(3): 597-603
[52]
Spongberg A L, Witter J D. Pharmaceutical compounds in the wastewater process stream in Northwest Ohio[J]. Science of the Total Environment, 2008, 397(1/3): 148-157
[53]
Tamtam F, van Oort F, Le Bot B, et al. Assessing the fate of antibiotic contaminants in metal contaminated soils four years after cessation of long-term waste water irrigation[J]. Science of the Total Environment, 2011, 409(3): 540-547
Boxall A B A, Johnson P, Smith E J, et al. Uptake of veterinary medicines from soils into plants[J]. Journal of Agricultural and Food Chemistry, 2006, 54(6): 2288-2297
[56]
Tolls J. Sorption of veterinary pharmaceuticals in soils: A review[J]. Environmental Science & Technology, 2001, 35(17): 3397-3406
Werner J J, Arnold W A, McNeill K. Water hardness as a photochemical parameter: Tetracycline photolysis as a function of calcium concentration, magnesium concentration, and pH[J]. Environmental Science & Technology, 2006, 40(23): 7236-7241
[59]
Carucci A, Cappai G, Piredda M. Biodegradability and toxicity of pharmaceuticals in biological wastewater treatment plants[J]. Journal of Environmental Science and Health Part A, 2006, 41(9): 1831-1842
[60]
Kim S, Eichhorn P, Jensen J N, et al. Removal of antibiotics in wastewater: Effect of hydraulic and solid retention times on the fate of tetracycline in the activated sludge process[J]. Environmental Science & Technology, 2005, 39(15): 5816-5823
[61]
Capone D G, Weston D P, Miller V, et al. Antibacterial residues in marine sediments and invertebrates following chemotherapy in aquaculture[J]. Aquaculture, 1996, 145(1/4): 55-75
[62]
Maki T, Hasegawa H, Kitami H, et al. Bacterial degradation of antibiotic residues in marine fish farm sediments of Uranouchi Bay and phylogenetic analysis of antibiotic-degrading bacteria using 16S rDNA sequences[J]. Fisheries Science, 2006, 72(4): 811-820
[63]
Li K X, Yediler A, Yang M, et al. Ozonation of oxytetracycline and toxicological assessment of its oxidation by-products[J]. Chemosphere, 2008, 72(3): 473-478
[64]
Dantas R F, Contreras S, Sans C, et al. Sulfamethoxazole abatement by means of ozonation[J]. Journal of Hazardous materials, 2008, 150(3): 790-794
[65]
Migliore L, Civitareale C, Cozzolino S, et al. Laboratory models to evaluate phytotoxicity of sulphadimethoxine on terrestrial plants[J]. Chemosphere, 1998, 37(14-15): 2957-2961
[66]
Thiele-Bruhn S, Beck I. Effects of sulfonamide and tetracycline antibiotics on soil microbial activity and microbial biomass[J]. Chemosphere, 2005, 59(4): 457-465
[67]
Halling-Sorensen B, Sengelov G, Tjornelund J. Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline-resistant bacteria[J]. Archives of Environmental Contamination and Toxicology, 2002, 42(3): 263-271
[68]
Zhang X X, Zhang T. Occurrence, Abundance, and diversity of tetracycline resistance genes in 15 sewage treatment plants across China and other global locations[J]. Environmental Science & Technology, 2011, 45(7): 2598-2604
[69]
Peak N, Knapp C W, Yang R K, et al. Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies[J]. Environmental Microbiology, 2007, 9(1): 143-151
[70]
Gulkowska A, Leung H W, So M K, et al. Removal of antibiotics from wastewater by sewage treatment facilities in Hong Kong and Shenzhen, China[J]. Water Research, 2008, 42(1/2): 395-403
[71]
Kümmerer K. Antibiotics in the aquatic environment- A review- Part I[J]. Chemosphere, 2009, 75(4): 417-434
EPA. Method 1694: Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biosolids by HPLC/MS/MS.2007[EB/OL][2009-12-10]. http://www.caslab.com/EPA-Methods/PDF/1694.pdf
[74]
Benito-Pena E, Urraca J L, Sellergren B, et al. Solid-phase extraction of fluoroquinolones from aqueous samples using a water-compatible stochiometrically imprinted polymer[J]. Journal of Chromatography A, 2008, 1208(1/2): 62-70
[75]
Castellari M, Gratacos-Cubarsi M, Garcia-Regueiro J A. Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography A, 2009, 1216(46): 8096-8100
[76]
Cristofani E, Antonini C, Tovo G, et al. A confirmatory method for the determination of tetracyclines in muscle using high-performance liquid chromatography with diode-array detection[J]. Analytica Chimica Acta, 2009, 637(1/2): 40-46
[77]
Herrera-Herrera A V, Hernandez-Borges J, Rodriguez-Delgado M A. Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives[J]. Journal of Chromatography A, 2009, 1216(43): 7281-7287
[78]
Golet E M, Strehler A, Alder A C, et al. Determination of fluoroquinolone antibacterial agents in sewage sludge and sludge-treated soil using accelerated solvent extraction followed by solid-phase extraction[J]. Analytical Chemistry, 2002, 74(21): 5455-5462
[79]
Turiel E, Martinesteban A, Tadeo J. Multiresidue analysis of quinolones and fluoroquinolones in soil by ultrasonic-assisted extraction in small columns and HPLC-UV[J]. Analytica Chimica Acta, 2006, 562(1): 30-35
[80]
Xu J, Wu L, Chen W P, et al. Simultaneous determination of pharmaceuticals, endocrine disrupting compounds and hormone in soils by gas chromatography-mass spectrometry[J]. Journal of Chromatography A, 2008, 1202(2): 189-195
[81]
Garcia-Mayor M A, Garcinuno R M, Fernandez-Hernando P, et al. Liquid chromatography-UV diode-array detection method for multi-residue determination of macrolide antibiotics in sheep's milk[J]. Journal of Chromatography A, 2006, 1122(1/2): 76-83
[82]
McDonald M, Mannion C, Rafter P. A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim and Dapsone residues in muscle by ultra-high-performance liquid chromatography-tandem mass spectrometry according to Commission Decision 2002/657/EC[J]. Journal of Chromatography A, 2009, 1216(46): 8110-8116
[83]
Bogialli S, D'Ascenzo G, Di Corcia A, et al. A simple and rapid assay based on hot water extraction and liquid chromatography-tandem mass spectrometry for monitoring quinolone residues in bovine milk[J]. Food Chemistry, 2008, 108(1): 354-360
[84]
Blasco C, Corcia A D, Picó Y. Determination of tetracyclines in multi-specie animal tissues by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry[J]. Food Chemistry, 2009, 116(4): 1005-1012
[85]
Jelic A, Petrovic M, Barcelo D. Multi-residue method for trace level determination of pharmaceuticals in solid samples using pressurized liquid extraction followed by liquid chromatography/quadrupole-linear ion trap mass spectrometry[J]. Talanta, 2009, 80(1): 363-371
[86]
Malintan N T, Mohd M A. Determination of sulfonamides in selected Malaysian swine wastewater by high-performance liquid chromatography[J]. Journal of Chromatography A, 2006, 1127(1/2): 154-160
[87]
Li J T, Chen L G, Wang X, et al. Determination of tetracyclines residues in honey by on-line solid-phase extraction high-performance liquid chromatography[J]. Talanta, 2008, 75(5): 1245-1252
[88]
Garces A, Zerzanova A, Kucera R, et al. Determination of a series of quinolones in pig plasma using solid-phase extraction and liquid chromatography coupled with mass spectrometric detection application to pharmacokinetic studies[J]. Journal of Chromatography A, 2006, 1137(1): 22-29
[89]
Nakata H, Kannan K, Jones P D, et al. Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography-mass spectrometry and fluorescence detection[J]. Chemosphere, 2005, 58(6): 759-766
[90]
Sun X L, He X W, Zhang Y K, et al. Determination of tetracyclines in food samples by molecularly imprinted monolithic column coupling with high performance liquid chromatography[J]. Talanta, 2009, 79(3): 926-934
[91]
Tsai W H, Huang T C, Huang J J, et al. Dispersive solid-phase microextraction method for sample extraction in the analysis of four tetracyclines in water and milk samples by high-performance liquid chromatography with diode-array detection[J]. Journal of Chromatography A, 2009, 1216(12): 2263-2269
[92]
Lillenberg M, Yurchenko S, Kipper K, et al. Simultaneous determination of fluoroquinolones, sulfonamides and tetracyclines in sewage sludge by pressurized liquid extraction and liquid chromatography electrospray ionization-mass spectrometry[J]. Journal of Chromatography A, 2009, 1216(32): 5949-5954
[93]
Mitani K, Kataoka H. Determination of fluoroquinolones in environmental waters by in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta, 2006, 562(1): 16-22
[94]
Nieto A, Borrull F, Marce R M, et al. Selective extraction of sulfonamides, macrolides and other pharmaceuticals from sewage sludge by pressurized liquid extraction[J]. Journal of Chromatography A, 2007, 1174(1/2): 125-131
[95]
Jacobsen A M, Halling-S？rensen B, Ingerslev F, et al. Simultaneous extraction of tetracycline, macrolide and sulfonamide antibiotics from agricultural soils using pressurised liquid extraction, followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography A, 2004, 1038(1/2): 157-170
[96]
McClure E LWong C S. Solid phase microextraction of macrolide, trimethoprim, and sulfonamide antibiotics in wastewaters[J]. Journal of Chromatography A, 2007, 1169(1/2): 53-62
[97]
Ding J, Ren N Q, Chen L G, et al. On-line coupling of solid-phase extraction to liquid chromatography-tandem mass spectrometry for the determination of macrolide antibiotics in environmental water[J]. Analytica Chimica Acta, 2009, 634(2): 215-221
[98]
Arnold D R, Granvil C P, Ward K W, et al. Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography B, 2008, 867(1): 105-110
[99]
Zhang Z, Liu J F, Shao B, et al. Time-resolved fluoroimmunoassay as an advantageous approach for highly efficient determination of sulfonamides in environmental waters[J]. Environmental Science & Technology, 2010, 44(3): 1030-1035
[100]
Shelver W L, Shappell N W, Franek M, et al. ELISA for sulfonamides and its application for screening in water contamination[J]. Journal of Agricultural and Food Chemistry, 2008, 56(15): 6609-6615
[101]
Suri C R, Boro R, Nangia Y, et al. Immunoanalytical techniques for analyzing pesticides in the environment[J]. Trac-Trends in Analytical Chemistry, 2009, 28(1): 29-39
[102]
Peippo P, Lovgren T, Tuomola M. Rapid screening of narasin residues in poultry plasma by time-resolved fluoroimmunoassay[J]. Analytica Chimica Acta, 2005, 529(1/2): 27-31
[103]
Watkinson A J, Murby E J, Costanzo S D. Removal of antibiotics in conventional and advanced wastewater treatment: Implications for environmental discharge and wastewater recycling[J]. Water Research, 2007, 41(18): 4164-4176
[104]
Zou S C, Xu W H, Zhang R J, et al. Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China: Impacts of river discharge and aquaculture activities[J]. Environmental Pollution, 2011, 159(10): 2913-2920
[105]
Managaki S, Murata A, Takada H, et al. Distribution of macrolides, sulfonamides, and trimethoprim in tropical waters: Ubiquitous occurrence of veterinary antibiotics in the Mekong Delta[J]. Environmental Science & Technology, 2007, 41(23): 8004-8010
[106]
Gulkowska A, He Y, So M K, et al. The occurrence of selected antibiotics in Hong Kong coastal waters[J]. Marine Pollution Bulletin, 2007, 54(8): 1287-1293
[107]
Hu X G, Zhou Q X, Luo Y. Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China[J]. Environmental Pollution, 2010, 158(9): 2992-2998
[108]
Vieno N M, H？rkki H, Tuhkanen T, et al. Occurrence of pharmaceuticals in river water and their elimination in a pilot-scale drinking water treatment plant[J]. Environmental Science & Technology, 2007, 41(14): 5077-5084
[109]
Ye Z Q, Weinberg H S, Meyer M T. Trace analysis of trimethoprim and sulfonamide, macrolide, quinolone, and tetracycline antibiotics in chlorinated drinking water using liquid chromatography electrospray tandem mass spectrometry[J]. Analytical Chemistry, 2007, 79(3): 1135-1144
[110]
Rosal R, Rodríguez A, Perdigón-Melón J A, et al. Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation[J]. Water Research, 2010, 44(2): 578-588
[111]
Leung H W, Minh T B, Murphy M B, et al. Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China[J]. Environment International, 2012, 42:1-9
[112]
Sacher F, Lang F T, Brauch H J, et al. Pharmaceuticals in groundwatersAnalytical methods and results of a monitoring program in Baden-Wurttemberg, Germany[J]. Journal of Chromatography A, 2001, 938(1/2): 199-210
[113]
Hamscher G, Pawelzick H T, Hoper H, et al. Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure[J]. Environmental Toxicology and Chemistry, 2005, 24(4): 861-868
[114]
Zhou L J, Ying G G, Zhao J L, et al. Trends in the occurrence of human and veterinary antibiotics in the sediments of the Yellow River, Hai River and Liao River in northern China[J]. Environmental Pollution, 2011, 159(7): 1877-1885
[115]
Golet E M, Xifra I, Siegrist H, et al. Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil[J]. Environmental Science & Technology, 2003, 37(15): 3243-3249
[116]
Lindberg R H, Olofsson U, Rendahl P, et al. Behavior of fluoroquinolones and trimethoprim during mechanical, chemical, and active sludge treatment of sewage water and digestion of sludge[J]. Environmental Science & Technology, 2006, 40(3): 1042-1048
[117]
Okuda T, Yamashita N, Tanaka H, et al. Development of extraction method of pharmaceuticals and their occurrences found in Japanese wastewater treatment plants[J]. Environment International, 2009, 35(5): 815-820
[118]
Jacobsen A M, Halling-Sorensen B, Ingerslev F, et al. Simultaneous extraction of tetracycline, macrolide and sulfonamide antibiotics from agricultural soils using pressurised liquid extraction, followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography A, 2004, 1038(1/2): 157-170
[119]
Karci A, Balclo？lu I A. Investigation of the tetracycline, sulfonamide, and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey[J]. Science of the Total Environment, 2009, 407(16): 4652-4664
[120]
Brambilla G, Patrizii M, De Filippis S P, et al. Oxytetracycline as environmental contaminant in arable lands[J]. Analytica Chimica Acta, 2007, 586(1/2): 326-329
Li W H, Shi Y L, Gao L H, et al. Investigation of antibiotics in mollusks from coastal waters in the Bohai Sea of China[J]. Environmental Pollution, 2012, 162: 56-62
[123]
Kumar K, Gupta S C, Baidoo S K, et al. Antibiotic uptake by plants from soil fertilized with animal manure[J]. Journal of Environmental Quality, 2005, 34(6): 2082-2085
[124]
Dolliver H, Kumar K, Gupta S. Sulfamethazine uptake by plants from manure-amended soil[J]. Journal of Environmental Quality, 2007, 36(4): 1224-1230
[125]
Grote M, Schwake-Anduschus C, Michel R, et al. Incorporation of veterinary antibiotics into crops from manured soil[J]. Landbauforschung Volkenrode, 2007, 57(1): 25-32
[126]
Christian T, Schneider R J, Farber H A, et al. Determination of antibiotic residues in manure, soil, and surface waters[J]. Acta Hydrochimica et Hydrobiologica, 2003, 31(1): 36-44
[127]
Halling-Sorensen B. Algal toxicity of antibacterial agents used in intensive farming[J]. Chemosphere, 2000, 40(7): 731-739
[128]
Gartiser S, Urich E, Alexy R, et al. Ultimate biodegradation and elimination of antibiotics in inherent tests[J]. Chemosphere, 2007, 67(3): 604-613
[129]
Junker T, Alexy R, Knacker T, et al. Biodegradability of C-14-labeled antibiotics in a modified laboratory scale sewage treatment plant at environmentally relevant concentrations[J]. Environmental Science & Technology, 2006, 40(1): 318-324
[130]
Hektoen H, Berge J A, Hormazabal V, et al. Persistence of antibacterial agents in marine-sediments[J]. Aquaculture, 1995, 133(3/4): 175-184
[131]
Marengo J R, Kok R A, OBrien K, et al. Aerobic biodegradation of (C-14)-sarafloxacin hydrochloride in soil[J]. Environmental Toxicology and Chemistry, 1997, 16(3): 462-471
[132]
Lai H T, Chien Y H, Lin J S. Long-term transformation of oxolinic acid in water from an eel pond[J]. Aquaculture, 2008, 275(1/4): 96-101
[133]
Migliore L, Civitareale C, Brambilla G, et al. Toxicity of several important agricultural antibiotics to Artemia[J]. Water Research, 1997, 31(7): 1801-1806
[134]
Wollenberger L, Halling-Sorensen B, Kusk K O. Acute and chronic toxicity of veterinary antibiotics to Daphnia magna[J]. Chemosphere, 2000, 40(7): 723-730
[135]
Batchelder A R. Chlortetracycline and Oxytetracycline Effects on Plant-Growth and Development in Soil Systems[J]. Journal of Environmental Quality, 1982, 11(4): 675-678
[136]
Baguer A J, Jensen J, Krogh P H. Effects of the antibiotics oxytetracycline and tylosin on soil fauna[J]. Chemosphere, 2000, 40(7): 751-757
[137]
Didelupis G D, Macri A, Civitareale C, et al. Antibiotics of zootechnical use-effects of acute high and low-dose contamination on daphnia-magna straus[J]. Aquatic Toxicology, 1992, 22(1): 53-59
[138]
Lanzky P F, HallingSorensen B. The toxic effect of the antibiotic metronidazole on aquatic organisms[J]. Chemosphere, 1997, 35(11): 2553-2561
[139]
Migliore L, Brambilla G, Casoria P, et al. Effect of sulphadimethoxine contamination on barley (Hordeum distichum L, Poaceae, Liliopsida)[J]. Agriculture Ecosystems & Environment, 1996, 60(2/3): 121-128
[140]
Migliore L, Brambilla G, Cozzolino S, et al. Effect on Plants of Sulfadimethoxine Used in Intensive Farming (Panicum-Miliacaum, Pisum-Sativum and Zea-Mays)[J]. Agriculture Ecosystems & Environment, 1995, 52(2/3): 103-110
[141]
Naslund J, Hedman J E, Agestrand C. Effects of the antibiotic ciprofloxacin on the bacterial community structure and degradation of pyrene in marine sediment[J]. Aquatic Toxicology, 2008, 90(3): 223-227
[142]
Halling-Sorensen B. Inhibition of aerobic growth and nitrification of bacteria in sewage sludge by antibacterial agents[J]. Archives of Environmental Contamination and Toxicology, 2001, 40(4): 451-460
[143]
Pruden A, Pei R, Storteboom H, et al. Antibiotic resistance genes as emerging contaminants: Studies in northern colorado [J]. Environmental Science & Technology, 2006, 40(23): 7445-7450
[144]
Luo Y, Mao D Q, Rysz M, et al. Trends in antibiotic resistance genes occurrence in the Haihe River, China[J]. Environmental Science & Technology, 2010, 44(19): 7220-7225
[145]
Schmitt H, Stoob K, Hamscher G, et al. Tetracyclines and tetracycline resistance in agricultural soils: Microcosm and field studies[J]. Microbial Ecology, 2006, 51(3): 267-276
[146]
Chee-Sanford J C, Aminov R I, Krapac I J, et al. Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities[J]. Applied and Environmental Microbiology, 2001, 67(4): 1494-1502
[147]
Seveno N A, Kallifidas D, Smalla K, et al. Occurrence and reservoirs of antibiotic resistance genes in the environment[J]. Reviews in Medical Microbiology, 2002, 13(1): 15-27
[148]
Smith M S, Yang R K, Knapp C W, et al. Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR[J]. Applied and Environmental Microbiology, 2004, 70(12): 7372-7377
