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环境化学  2015 

诺氟沙星的氯化反应及其遗传毒性的变化

Keywords: 诺氟沙星,氯化反应,SOS/umu测试法,遗传毒性

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Abstract:

分别以诺氟沙星初始浓度为10μg·l-1和25mg·l-1进行氯化消毒实验,用HPLC和SOS/umu遗传毒性测试方法,分别测定不同氯化消毒反应时间后残留诺氟沙星的浓度和遗传毒性,反应速度常数分别为0.0243min-1和0.0226min-1;在高浓度反应组,反应45min后反应液的遗传毒性效应有明显的提高,其EC50为131nmol·l-1,低于反应前的EC50(181nmol·l-1),表明在反应过程中生成了遗传毒性高于母体的中间产物.

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