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化工进展  2015 

分子识别型智能微囊的制备及其控制释放特性

DOI: 10.16085/j.issn.1000-6613.2015.01.032

Keywords: 微囊,分子识别,控制释放,微流体学,乳液,传质

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Abstract:

采用微流控乳化和紫外光照引发制备聚(N-异丙基丙烯酰胺-共聚-丙烯酸)微囊,然后通过缩合反应将氨基化β-环糊精(ECD)引入微囊成功制备得到聚(N-异丙基丙烯酰胺-共聚-丙烯酸/氨基化β-环糊精)(PNA-ECD)微囊。PNA-ECD微囊具有明显的核壳型结构和良好的单分散性。微囊的平均直径为470μm,CV值为2.98%。PNA-ECD微囊在识别模型芳环分子8-苯胺-1-萘磺酸铵盐(ANS)后能等温收缩从而实现对内载药物的控制释放。32℃时,微囊内部的模型药物异硫氰酸荧光素标记葡聚糖(FITC-dextran)在纯水中无明显释放,而在加入2.0mmol/LANS溶液16min后,微囊内部约70%的FITC-dextran释放到微囊外部。研究结果对制备单分散分子识别型智能微囊及研究其控制释放特性提供有价值的理论指导和实验基础。

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