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化工进展  2015 

pH值响应聚乙二醇化壳聚糖基隐形纳米胶束的制备及其载药性能

DOI: 10.16085/j.issn.1000-6613.2015.01.030

Keywords: 两亲性壳聚糖,聚乙二醇单甲醚,pH值响应性,自组装胶束

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Abstract:

聚乙二醇单甲醚(mPEG)先经过氯乙酸羧化后,再通过酰化反应接枝到双烷基壳聚糖上,制备高接枝度的N,N-双十二烷基-3,6-O-mPEG-壳聚糖(PEDLCS)双亲性衍生物,用1HNMR、FTIR、EA等对产物进行表征,并用透析法制得PEDLCS载酮洛芬(KP)胶束。结果表明,PEDLCS在水溶液中能自组装形成胶束,CMC值为0.1170mg/mL;载药胶束的最优投料比为KP/PEDLCS=0.81,载药量34.48%,包封率65.78%,粒径155.1nm,Zeta电位-31.6mV。载药胶束在不同pH值条件下的响应性实验表明,随着pH值的减小,胶束的稳定性降低,胶束粒径变大,具有可逆性。pH值响应范围符合肿瘤细胞微环境(pH值为7.2~6.0),有望成为具有pH值响应主动靶向的隐形纳米胶束。

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