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化工进展  2015 

O-季铵化-N-(4-十二烷氧基)壳聚糖苯甲醛席夫碱的制备及胶束pH响应性

DOI: 10.16085/j.issn.1000-6613.2015.02.028, PP. 484-489

Keywords: 壳聚糖,对烷氧基苯甲醛,席夫碱,胶束

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Abstract:

制备双亲性的O-季铵化-N-(4-十二烷氧基)壳聚糖苯甲醛席夫碱(QA-CS-DBA),采用FTIR、1HNMR及元素分析对产物进行表征。通过超声法制备QA-CS-DBA载酮洛芬胶束,考察胶束的临界胶束浓度、粒径、Zeta电位、载药量和包封率,并对胶束在不同pH值条件下的药物释放行为及Zeta电位变化进行研究。结果表明,QA-CS-DBA能将酮洛芬包载于胶束疏水内核,载药量为39.37%,包封率为46.04%,载药胶束粒径为341nm,Zeta电位为30.8mV。胶束Zeta电位及载药胶束的药物释放行为具有pH响应性。

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