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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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含醛基可降解嵌段共聚物的合成及其生物缀合
DOI: 10.11777/j.issn1000-3304.2015.14322, PP. 459-465
Keywords: 醛基,可降解,RAFT共聚,生物缀合
Abstract:
以PEO-DDMAT为大分子RAFT试剂、BPO为引发剂,调控含醛基单体4-乙烯基苯甲醛(VBA)与不饱和环缩醛单体5,6-苯基-2-亚甲基-1,3-二氧七环(BMDO)的RAFT共聚合,获得一种新型含醛基、可降解的两亲性嵌段共聚物PEO-b-poly(VBA-co-BMDO),并对不同单体投料比下的共聚行为进行了研究.由于聚合物主链含有酯基,可以在水中碱性条件下进行降解.细胞毒性分析表明其具有良好生物相容性.该嵌段聚合物还可以通过醛基-氨氧基"点击"反应和模型生物分子氨氧基胆固醇(H2NO-Chol)形成稳定的聚合物-生物分子缀合物,该缀合物能在水溶液中自组装成纳米胶束.结果表明PEO-b-poly(VBA-co-BMDO)可以作为聚合物载体缀合含氨氧基的药物分子,在生物医药方面有良好的应用前景.
| [1] | 1 Pack D W, Hoffman A S,Pun S,Stayton P S.Nat Rev Drug Discovery,2005,4:581~593
|
| [2] | 2 Duncan R.Nat Rev Drug Discovery,2003,2:347~360
|
| [3] | 3 Boyer C,Bulmus V,Davis T P,Ladmiral V,Liu J Q,Perrier S.Chem Rev,2009,109:5402~5436
|
| [4] | 4 Harris J M,Chess R B.Nat Rev Drug Discovery,2003,2:214~221
|
| [5] | 5 Bae Y,Fukushima S,Harada A,Kataoka K.Angew Chem Int Ed,2003,42:4640~4643
|
| [6] | 6 Xiao N Y,Li A L,Liang H,Lu J.Macromolecules,2008,41:2374~2380
|
| [7] | 7 Rossi N A A,Zou,Y Q,Scott M D,Kizhakkedathu J N.Macromolecules,2008,41:5272~5282
|
| [8] | 8 Godwin A,Hartenstein M,Müller A H E,Brocchini S.Angew Chem Int Ed,2001,40:594~597
|
| [9] | 9 Liu S,Maheshwari R,Kiick K L.Macromolecules,2009,42:3~13
|
| [10] | 10 Liu J Q,Bulmus V,Herlambang D L,Kowollik C B,Stenzel M H,Davis T P.Angew Chem Int Ed,2007,46:3099~3103
|
| [11] | 21 Shi M,Li A L,Liang H,Lu J.Macromolecules,2007,40:1891~1896
|
| [12] | 22 Sun G R,Cheng C,Wooley K L.Macromolecules,2007,40:793~795
|
| [13] | 23 Sun G R,Fang H F,Cheng C,Lu P,Zhang K,Walker A V,Taylor J S A,Wooley K L.ACS Nano,2009,3:673~681
|
| [14] | 24 Bailey W J,Ni Z D,Wu S R.Macromolecules,1982,15:711~714
|
| [15] | 25 Yuan J Y,Pan C Y,Tang B Z.Macromolecules,2001,34:211~214
|
| [16] | 11 Heredia K L,Bontempo D,Ly T,Byers J T,Halstenberg S,Maynard H D.J Am Chem Soc,2005,127:16955~16960
|
| [17] | 12 Lele B S,Murata S,Matyjaszewski K,Russell A J.Biomacromolecules,2005,6:3380~3387
|
| [18] | 13 Hawker C J,Bosman A W,Harth E.Chem Rev,2001,101:3661~3688
|
| [19] | 14 Matyjaszewski K,Xia J.Chem Rev,2001,101:2921~2990
|
| [20] | 15 Kamigaito M,Ando T,Sawamoto M.Chem Rev,2001,101:3689~3745
|
| [21] | 16 Iha R K,Wooley K L,Nystron A M,Burke D J,Hawker C J.Chem Rev,2009,109:5620~5686
|
| [22] | 17 Slomkowski S.Prog Polym Sci,1998,23:815~874
|
| [23] | 18 Tao L,Mantovani G,Lecolley F,Haddleton D M.J Am Chem Soc,2004,126:13220~13221
|
| [24] | 19 Liu H,Jiang X Z,Fan J,Wang G H,Liu S Y.Macromolecules,2007,40:9074~9083
|
| [25] | 20 Lemieux G A,Bertozzi C R.Trends Biotechnol,1998,16:506~513
|
| [26] | 26 Yuan J Y,Pan C Y.Eur Polymer J,2002,38:1565~1571
|
| [27] | 27 Wickel H,Agarwal S,Greiner A.Macromolecules,2003,36:2397~2403
|
| [28] | 28 Wickel H,Agarwal S.Macromolecules,2003,36:6152~6159
|
| [29] | 29 Ren L Q,Agarwal S.Macromol Chem Phys,2007,208:245~253
|
| [30] | 30 Lutz J F,Andrieu J,Uzgun S,Rudolph C,Agarwal S.Macromolecules,2007,40:8540-8543
|
| [31] | 31 He T,Zou Y F,Pan C Y.Polymer J,2002,34:138~143
|
| [32] | 32 Bigot Y L,Delmas M,Gaset A.Synth Commun,1983,13:177~182
|
| [33] | 33 Rieger J,Stoffelbach F,Bui C,Alaimo D,Jér？me C,Charleux B.Macromolecules 2008,41:4065~4068
|
| [34] | 34 Ma M M,Chatterjee S,Zhang M,Bong D.Chem Commun,2011,47:2853~2855
|
| [35] | 35 Schmalenberg K E,Frauchiger L,Nikkhouy-Albers L,Uhrich K E.Biomacromolecules,2009,2:851~855
|
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