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OALib Journal期刊
ISSN: 2333-9721
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乙基纤维素接枝聚己内酯药物缓释膜的制备及释药行为
DOI: 10.11777/j.issn1000-3304.2015.15068, PP. 1208-1215
Keywords: 接枝共聚物,结晶,降解,药物释放
Abstract:
在离子液体体系中通过开环聚合制备了用于药物缓释膜的乙基纤维素含量可控的乙基纤维素接枝聚己内酯共聚物(EC-g-PCL),并由1H-NMR谱图计算得到共聚物中[ε-CL]/[EC]葡萄糖单元的最大摩尔比为7∶1.AFM测试结果表明共聚物的表面随着PCL含量的增加而变得更加粗糙.EC-g-PCL共聚物中PCL链段可以结晶,且随着PCL含量的降低,结晶度逐步减小.偏光显微镜照片显示共聚物中PCL含量低于20%时,无法观测到清晰的PCL球晶结构,而高于这个含量的共聚物则可生成环带球晶.所有共聚物薄膜在PBS溶液中降解30天的失重量均大于纯PCL,且随着EC含量的增加失重量从2.51%增加到8.31%.EC链的引入促进了PCL的降解.通过对负载药物双氯酚酸的共聚物薄膜的释药行为研究发现,其药物突释量和最大累计释放量均高于纯PCL的,释药动力学满足Ritger-Pappas方程lnQ=0.3846lnt-1.8538,药物释放机制为Fickian扩散型,而PCL膜为non-Fickian扩散,即扩散与骨架溶蚀机制相结合.
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