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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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PNIPAM-b-聚碳酸酯温敏胶束的制备及用作药物控制释放载体的研究
DOI: 10.3724/SP.J.1105.2011.11120, PP. 895-902
Keywords: 嵌段型两亲性温敏胶束,PNIPAM,生物可降解聚碳酸酯,酶促聚合,药物控制释放,毒性
Abstract:
以多孔硅球固定化猪胰脂肪酶(IPPL)为催化剂,温敏性HO-PNIPAM为大分子引发剂,5-甲基-5-烯丙氧羰基-三亚甲基碳酸酯(MAC)和5,5-二甲基三亚甲基碳酸酯(DTC)为共聚单体,通过开环聚合合成了不同结构比例的两亲性嵌段型共聚物P(MAC-co-DTC)-b-PNIPAM.该嵌段型共聚物在水中可自组装形成稳定的胶束,其CMC值为20~60mg/L,干态粒径20~70nm,LCST值为38~43℃,细胞毒性实验显示其具有良好的生物相容性.以疏水性药物醋酸泼尼松为模型药物,研究了嵌段型共聚物胶束对药物的负载及释放行为,结果表明载药胶束具有良好的温敏性药物释放性能.
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