|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
具有温敏性的混合胶束的制备与表征及药物体外释放
DOI: 10.3724/SP.J.1105.2011.10301, PP. 1237-1243
Keywords: 混合胶束,聚(N-异丙基丙烯酰胺),胆固醇,聚乙二醇,药物释放
Abstract:
通过原子转移自由基聚合(ATRP)合成了以胆固醇为端基的两亲性聚(N-异丙基丙烯酰胺)(Chol-PNIPAAm),利用FTIR、1H-NMR和GPC等方法表征了聚合物的结构.将该两亲性温敏聚合物与聚乙二醇单甲醚硬脂酸酯(mPEG-SA)通过简单混合,即可得到稳定的Chol-PNIPAAm/mPEG-SA混合胶束体系.与细胞膜中胆固醇通过嵌入磷脂疏水层达到稳定细胞膜的现象类似,Chol-PNIPAAm的胆固醇和mPEG-SA的硬脂酸共同构成了复合胶束的疏水内核,使得混合胶束具有更低的临界胶束浓度(CMC).动态光散射(DLS)研究表明,混合胶束不仅更稳定,而且具有温度响应性,其粒径在33~35℃之间可逆转变.药物体外释放结果表面,温度的升高会导致药物释放加快,PNIPAAm含量越高,释放速度越大.
| [1] | 17 Harada A,Kataoka A.J Controlled Release,2001,72:85~91
|
| [2] | 18 Gohy J F,Varshney S K,Jérme R.Macromolecules,2001,34:3361~3366
|
| [3] | 19 Kang N,Perron M E,Prud'homme R E,Zhang Y,Gaucher G,Leroux J C.Nano Lett,2005,5:315~319
|
| [4] | 20 KimS H,TanJ P K,Nederberg F,Fukushima K,Yang Y Y,Waymouth R M,Hedrick J L.Macromolecules,2009,42:25~29
|
| [5] | 21 Zhai Zhonghe(翟中和),Wang Xizhong(王喜忠),Ding Mingxiao(丁明孝).Cell Biology(细胞生物学),1st ed,Beijing(北京),Higher Education Press(高等教育出版社),2000.76~82
|
| [6] | 22 Ciampolini M,Nardi N.Inorg Chem,1966,5(1):41~44
|
| [7] | 23 Lutz J F,Pfeifer S,Zarafshani Z.QSAR Comb Sci,2007,26:1151 ~ 1158
|
| [8] | 5 Li Zhenquan(李振泉),Qian Jian(钱健),Cao Xulong(曹绪龙),Song Xinwang(宋新旺),Wu Feipeng(吴飞鹏).Acta Polymerica Sinica(高分子学报),2010 (3):329~333
|
| [9] | 6 Hawker C J,Wooley K L.Science 2005,309:1200~1205
|
| [10] | 7 Oh J K,Siegwart D J,Lee H-I,Sherwood G,Peteanu L,Hollinger J O,Kataoka K,Matyjaszewski K.J Am Chem Soc 2007,129:5939~5945
|
| [11] | 10 Deng Gang(邓刚),Yao Shanjing(姚善泾),Lin Dongqian(林东强).Acta Polymerica Sinica(高分子学报),2006,(4):569~573
|
| [12] | 16 Harada A,Kataoka A.Science,1999,283:65~67
|
| [13] | 1 Jones M C, Leroux J C.Eur J Pharm Biopharm,1999,48:101~111
|
| [14] | 2 Kataoka K,Harada A,Nagasaki Y.Adv Drug Deliv Rev,2001,47:113~131
|
| [15] | 3 Kwon G S.Crit Rev Ther Drug Carr Syst,2003,20:357~403
|
| [16] | 4 Gaucher G,Dufresne M-H,Sant V P,Kang N,MaysingerD,Leroux J C.J Control Release,2005,109:169~188
|
| [17] | 8 Desai P R,Jain N J,Sharma P K,Bahadur P.Colloids Surf A:Physicochem Engng Aspects,2001,178:57~69
|
| [18] | 9 Zheng Y,Davis H T.Langmuir,2000,16:6453~6459
|
| [19] | 11 Yan J J,Ji WX,Chen E Q,Li Z C,Liang D H.Chinese J Polym Sci,2010,28(3):437~447
|
| [20] | 12 Riess G.Progress in Polymer Science,2003,28:1107~1170
|
| [21] | 13 Harada A,Kataoka K.J Controlled Release,2001,72:85~91
|
| [22] | 14 Li G,Shi L,Ma R,An Y,Huang N.Angew Chem Int Ed,2006,45:4959~4962
|
| [23] | 15 Lo C L,Huang C K,Lin K M,Hsiue G H.Biomaterials,2007,28:1225-1235
|
| [24] | 24 Wilhelm M,Zhao C L,Wang Y,Xu R,Winnik M A,Mura J L,Riess G,Croucher M D.Macromolecules,1991,24:1033~1040
|
| [25] | 25 Astafieva I,Zhong XF,Eisenberg A.Macromolecules,1993,26:7339~7352
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
