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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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聚电解质微球多级自组装制备双重药物载体
DOI: 10.3724/SP.J.1105.2011.11025, PP. 1461-1469
Keywords: 壳聚糖,胶束,静电自组装,多级自组装,双重载药
Abstract:
将表面带正电荷的壳聚糖(CS)微球和表面带负电荷的聚(L-谷氨酸)-b-聚氧化丙烯-b-聚(L-谷氨酸)(GPG)胶束共混,制备了CS/GPG聚集体水溶液体系.通过改变CS/GPG的共混比例,研究了CS微球和GPG胶束形成稳定CS/GPG聚集体水溶液体系的配比范围,并对其粒径分布和表面电位进行了表征.在此基础上,将CS微球作为亲水性药物阿司匹林(Asp)的载体,GPG胶束作为疏水性药物阿霉素(DOX)的载体,通过多级自组装形成一种新型双重载药体系.研究了该双重药物载体的体外药物释放行为.结果表明,Asp和DOX都具有很好的药物缓释效果,并且2种药物的释药行为都具有明显的pH值响应性.
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