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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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阴离子型含氟两亲接枝共聚物的合成及其胶束化行为研究
DOI: 10.3724/SP.J.1105.2011.10382, PP. 1402-1411
Keywords: 阴离子,两亲接枝共聚物,胶束化行为,含氟聚合物,荧光光谱,牛血清蛋白
Abstract:
以聚乙二醇甲醚甲基丙烯酸酯(MPEGMA)为大分子单体,甲基丙烯酸六氟丁酯(HFMA)、对苯乙烯磺酸钠(NaSS)为共聚单体,采用大分子单体接枝共聚法,制备了一种阴离子型含氟两亲接枝共聚物P(HFMA-co-NaSS)-g-PEG.利用FTIR、1H-NMR和19F-NMR对共聚物的分子结构进行了表征.表面张力法测定了P(HFMA-co-NaSS)-g-PEG的临界胶束浓度(CMC),发现随着PEG支链和阴离子含量的增加,CMC逐渐变大;采用动态光散射法(DLS)研究发现,随着胶束溶液浓度和PEG支链的增加,胶束粒径逐渐增大;荧光光谱法研究了P(HFMA-co-NaSS)-g-PEG自组装胶束与牛血清蛋白(BSA)的相互作用,结果表明阴离子型含氟两亲接枝共聚物可以使BSA的荧光强度减弱,且随着共聚物浓度、含氟链段以及阴离子含量的提高,荧光强度逐渐降低;通过透射电子显微镜(TEM)研究了P(HFMA-co-NaSS)-g-PEG胶束以及P(HFMA-co-NaSS)-g-PEG/BSA聚集体的形貌,结果表明P(HFMA-co-NaSS)-g-PEG在水溶液中可自组装成核壳结构明显的胶束粒子,随着含氟链段的减少,共聚物胶束由树叶状转变成规则的球状结构,同时,发现P(HFMA-co-NaSS)-g-PEG胶束对BSA分子有明显的吸附作用.
| [1] | 1 Wang Y, Gao S J,Ye W H,Yoon H S,Yang Y Y.Nat Mater,2006,5: 791~796
|
| [2] | 3 Wang D Q,Tan J J,Kang H L,Ma L,Jin X,Liu R G,Huang Y.Carbohydr Polym,2011,84: 195~202
|
| [3] | 4 Dong H B,Xu Y Y,Yi Z,Chinese J Polym Sci,2009,27(6): 813~820
|
| [4] | 5 Lee H,Jeong J H,Park T G.J Controlled Release,2001,76: 183~192
|
| [5] | 6 Shi L,Tang G P,Gao S J,Ma Y X,Liu B H,Li Y,Zeng J M,Ng Y K,Leong K W,Wang S.Gene Ther,2003,10: 1179~1188
|
| [6] | 7 Fabienne D,Nicolas M,Bernard U,Nathalie L,Marcus B,Veronique P.Eur J Pharm Biopharm,2009,73: 230~238
|
| [7] | 8 Hussain H,Busse K,Kressler J.Macromol Chem Phys,2003,204: 936~946
|
| [8] | 9 Ojogun V A,Lehmler H J,Knutson B L.J Colloid Interface Sci,2009,338: 82~91
|
| [9] | 10 He J L,Ni P H,Liu C C.J Polym Sci Part A: Polym Chem,2008,46: 3029~3041
|
| [10] | 13 Najafi F,Sarbolouki M N.Biomaterials,2003,24: 1175~1182
|
| [11] | 14 Harada A,Kataoka K.Science,1999,283: 65~67
|
| [12] | 15 He Yuan(何嫄),Yu Lin(於麟),Tan Songwei(谭松巍),Jiang Hongliang(蒋宏亮),Tu Kehua(涂克华),Wang Liquan(王立群).Acta Polymerica Sinica(高分子学报),2010,(7): 897~902
|
| [13] | 16 Wang J,Zhang Y Y,Guo Y,Zhang L,Xu R,Xing Z Q,Wang S X,Zhang X D.Dyes Pigments,2009,80: 271~278
|
| [14] | 17 Zsila F,Bikadi Z,Simonyi M.Biochem Pharmacol,2003,65: 447~456
|
| [15] | 19 Xiong Shengdong(熊圣东),Li Ling(李玲),Wu Shuilin(吴水林),Yi Changfeng(易昌凤),Xu Zushun(徐祖顺).Acta Polymerica Sinica(高分子学报),2010,(2):149~155
|
| [16] | 21 Zhao Li(赵莉),Yan Yun(阎云),Huang Jianbin(黄建滨).Acta Phys Chim Sin(物理化学学报),2010,(26): 840-849
|
| [17] | 23 Yan C N,Zhang H X,Mei P,Liu Y.Chin J Chem,2005,23: 1151~1156
|
| [18] | 25 Walton A G,Maenpa F C.J Colloid Interface Sci,1979,72: 265~278
|
| [19] | 29 Lee J H,Khang G,Lee J W,Lee H B.J Colloid Interface Sci,1998,205: 323~330
|
| [20] | 32 Li L,Xu Z S,Song G W.J Fluorine Chem,2009,130: 225~230
|
| [21] | 37 Choi C Y,Chae S Y,Nah J W.Polymer,2006,47: 4571~4580
|
| [22] | 38 Li Y Y,Zhang X Z,Kim G C,Cheng H,Cheng S X,Zhuo R X.Small,2006,2: 917~923
|
| [23] | 39 Wang H J,Zhao P Q,Liang X F,Gong X Q,Song T,Niu R F,Chang J.Biomaterials,2010,31: 4129~4138
|
| [24] | 2 Zhang M F,Drechsler M,Muller A H E.Chem Mater,2004,16: 537~543
|
| [25] | 11 Kavanagh C A,Rochev Y A,Gallagher W M,Dawson K A,Keenan A K.Pharmacol Therapeut,2004,102: 1~15
|
| [26] | 12 Lucke A,Fustella E,Tebmar J,Gazzaniga A,Gopferich A.J Controlled Release,2002,80: 157~168
|
| [27] | 18 Dockal M,Carter D C,Ruker F.J Biol Chem,2000,275: 3042~3050
|
| [28] | 20 Xiong S D,Li L,Wu S L,Xu Z S,Chu P K.J Polym Sci Part A: Polym Chem,2009,47: 4895~4907
|
| [29] | 22 Ding Min(丁敏),Guo Lihua(郭丽华),Zhang Ling(张玲),Wu Q(伍青).Progress in Chemistry(化学进展),2010,(22): 458~464
|
| [30] | 24 Kasai S,Horie T,Mizuma T,Awazu S.J Pharm Sci,1987,76: 387~392
|
| [31] | 26 Li L,Wang Y X,Song G W,Wu S L,Chu P K,Xu Z S.J Fluorine Chem,2009,130: 870~877
|
| [32] | 27 Cole M A,Thissen H,Losic D,Voelcker N H.Surf Sci,2007,601: 1716~1725
|
| [33] | 28 Sun F Q,Li X S,Xu J K,Cao P T.Chinese J Polym Sci.2010,28(5): 705~713
|
| [34] | 30 Zhu A P,Yuan L H,Chen T,Wu H,Zhao F.Carbohydr Polym,2007,69: 363~370
|
| [35] | 31 Park J H,Bae Y H.Biomaterials,2002,23: 1797~1808
|
| [36] | 33 Zhang J H,Sun Z Q,Yang B.Curr Opin in Colloid Interface Sci,2009,14: 103~114
|
| [37] | 34 Chen T,Wang L,Jiang G H,Wang J J,Wang X J,Zhou J F,Wang W.Eur Polym J,2006,42: 687~693
|
| [38] | 35 Kim J K,Yang S Y,Lee Y,Kim Y.Prog Polym Sci,2010,35: 1325~1349
|
| [39] | 36 Zhang K,Yu A,Wang D W,Yang W M,Li J N,Zhang X R,Wang Y J.Mater Lett,2011,65: 293~295
|
| [40] | 40 Lila A S A,Doi Y,Nakamura K,Ishida T,Kiwada H.J Controlled Release,2010,142: 167~173
|
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