OALib Journal期刊
古紫质等光驱质子泵以及该类活性蛋白质与聚合物的功能复合材料
DOI: 10.3724/SP.J.1105.2012.12051
Keywords: 细菌视紫红质 ,古紫质 ,紫膜 ,质子泵 ,光电响应 ,光色响应 ,嵌段共聚物 ,功能高分子材料 ,复合材料 ,信息功能材料
Abstract:
将具有生物活性的蛋白质与具有良好加工和力学性能的合成高分子相结合制备高性能的杂化材料是材料科学一个新的生长点.本专论聚焦于对具有光驱质子泵功能的两类活性蛋白质——细菌视紫红质(BR)与古紫质4(AR4)的研究,其中BR作为一个著名的膜蛋白已有四十余年的研究历史,而AR4则为中国科研人员十余年前所发现.综述了AR4的研究,并对AR4和BR进行了对比,进一步介绍了光敏蛋白质(BR和AR4)与聚合物基质复合制备新型功能高分子材料的工作,还介绍了该类光敏蛋白质的基因工程改造以及蛋白质/聚合物复合膜用于信息材料方面的探索工作.论文总结了一系列创新成果,如(1)在光敏蛋白质的质子泵机理方面,提出了"弱偶联模型"并解释了AR4具有与BR相反的质子释放和提取时间顺序的内在机理;(2)光敏蛋白质与聚合物复合膜相关的高分子水凝胶和蛋白质聚集状态的研究,并发现与均聚物和两亲性小分子不同,两亲性嵌段共聚物可导致光敏蛋白质中间体的寿命有数量级的延长;(3)发展了光敏蛋白质与聚合物复合膜的制备技术,所得到的材料不仅保持了光学活性,其蛋白质的光学响应性能还得到进一步改善;(4)发现了含光敏蛋白质的紫膜强烈抗拒哺乳动物细胞黏附的新功能;(5)尝试将该蛋白质和聚合物的复合膜作为信息材料,实现了全光宽带图像显示.进一步展望了此类光敏蛋白质的后续研究和潜在的应用前景.
References
[1] 2 Zhang Yanxia(张燕霞),Yu Qian(于谦),Wu Zhaoqiang(武照强),Zhou Feng(周峰),Li Xin(李鑫),Chen Hong(陈红).Acta Polymerica Sinica(高分子学报),2011,(6):622~627 [2] 4 Chen Jingxiao(陈荆晓),Wang Huiyuan(王慧媛),Xu Xiaoding(许小丁),Chen Weihai(陈巍海),Zhang Xianzheng(张先正).Acta Polymerica Sinica(高分子学报),2011,(8):799~811 [3] 5 Zhang Chunqiu(张春秋),Luo Quan(罗全),Liu Junqiu(刘俊秋).Acta Polymerica Sinica(高分子学报),2011,(9):1020~1025 [4] 13 Wen Jianchuan(文建川),Yao Jinrong(姚晋荣),Shao Zhengzhong(邵正中).Acta Polymerica Sinica(高分子学报),2011,(1):12~23 [5] 15 Lozier R,Bogomolni R A,Stoeckenius W.Biophys J,1975,15:955~962 [6] 18 Kimura Y,Vassylyev D G,Miyazawa A,Kidera A,Matsushima M,Mitsuoka K,Murata K,Hirai T,Fujiyoshi Y.Nature,1997,389:206~211 [7] 24 Gong Qinggan(龚勤敢),Zhao Youyuan(赵有源),Huang Yuhua(黄玉华),Cheng Linbing(陈凌冰),Li Fuming(李富铭),Liujian(刘坚),Ding Jiandong(丁建东),Li Qingguo(李庆国).Acta Biophysica Sinica(生物物理学报),1999,15(1):137~143 [8] 26 Huang Y H,Zhao Y Y,Zhang Z B,Ouyang X P,Gong Q G,Yang Q,Cheng L B,Li F M,Liu J,Ding J D,Li Q G.Chin Phys Lett,2000,17(4):301~303 [9] 27 Huang Yuhua(黄玉华),Zhao Youyuan(赵有源),Gong Qinggan(龚勤敢),Yang Qun(杨群),Cheng Linbing(陈凌冰),Li Fuming(李富铭),Liujian(刘坚),Ding Jiandong(丁建东),Li Qingguo(李庆国).Chin J Lasers(中国激光),2000,27(2):187~192 [10] 28 Liang B,Li L Q,Li M L,Li B F,Jiang L.In:Lewis K L,Meerholz K.Eds.Proceedings of The Society of Photo-optical Instrumentation Engineers.San Jose:SPIE-Int Soc Optical Engineering,2000,4104:64~70 [11] 29 Xiang Y,Zhang J,Liu Y,Guo Z B,Lu S F.J Membrane Sci,2011,367:325~331 [12] 30 Huang Yuhua(黄玉华),Zhao Youyuan(赵有源),Ouyang Xiaoping(欧阳晓平),Gong Qinggan(龚勤敢),Yang Qun(杨群),Cheng Lingbing(陈凌冰),Li Fuming(李富铭),Zhang Zhongbin(张忠宾),Liu Jian(刘坚),Ding Jiandong(丁建东),Li Qingguo(李庆国).Acta Opt Sinica(光学学报),2001,21(1):106~110 [13] 32 Zeng L Y,Wu A G,Wang Y Z,Pu S L,Ding J D.Microsc Res Techniq,2012,36(11):724~728 [14] 36 Miyasaka T,Koyama K.Appl Opti,1993,32:6371~6379 [15] 37 Birge R R,Gillespie N B,Izaguirre,E W,Kusnetzow A,Lawrence A F,Singh D,Song Q W,Schmidt E,Stuart J A,Seetharaman S,Wise K J.J Phys Chem B,1999,103:10746~10766 [16] 38 Li M L,Li B F,Jiang L.Langmuir,2000,16:5503~5505 [17] 43 Lukashev E P,Govindjee R,Kono M,Ebrey T G,Sugiyama Y,Mukohata Y.Photochem Photobiol,1994,60:69~75 [18] 44 Wang H,Zhan S X,Sun Q G,Xu D Q,Zhao W,Huang W D,Li Q G.Chin Sci Bull,2000,45(12):1108~1113 [19] 46 Lu M,Balashov S P,Ebrey T G,Liu J,Huang L,Wang Y,Huang W D,Ding J D,Li Q G.Biophys J,2001,80:2730~2730 [20] 47 Brown L S.Biochemistry(Moscow),2001,66:1546~1554 [21] 49 Ihara K,Umemura T,Katagiri I,Kitajima-Ihara T,Sugiyama,Y,Kimura Y,Mukohata Y.J Mol Biol,1999,285:163~174 [22] 50 Wu J,Huang L,Liu J,Ming M,Li Q G,Ding J D.Chin J Chem,2005,23:330~333 [23] 51 Ming M,Lu M,Balashov S P,Ebrey T G,Li Q G,Ding J D.Biophys J,2006,90:3322~3332 [24] 52 Chow B Y,Han X,Dobry A S,Qian X F,Chuong A S,Li M J,Henninger M A,Belfort G M,Lin Y X,Monahan P E,Boyden E S.Nature,2010,463:98~102 [25] 54 Gao W Y,Yu Z W,Chin J Chem,2008,26:1596~1600 [26] 55 Tao N,Cheng J,Wei L,Yue J C.Langmuir,2009,25:5747~5752 [27] 57 Ozga K,Reshak A H,Berdowski J,Tylczynski Z,Wojciechowski A,Slezak A,Kityk I V.Mater Lett,2011,65:1734~1736 [28] 58 Taran M,Monazah A,Asadi N.Int J Biol.Macromol,2011,49:955~957 [29] 59 Yoshimura K,Kouyama T.J Mol Biol,2008,375:1267~1281 [30] 60 Lobasso S,Lopalco P,Vitale R,Saponetti M S,Capitanio G,Mangini V,Milano F,Trotta M,Corcelli A.Photochem Photobiol,doi:10.1111/j.1751~1097.2012.01089.x [31] 62 Wu A G,Jia Z H,Schaper A,Noll F,Hampp N A.Langmuir,2006,22:5213~5216 [32] 63 Tang L,Sun Q A,Li Q G,Huang Y B,Wei Q Q,Zhang Y,Hu J,Zhang Z H,Li M Q,Yang F J.Chin Sci Bull,2001,46:1897~1900 [33] 64 Zimanyi L,Varo G,Chang M,Ni B F,Needleman R,Lanyi J K.Biochemistry,1992,31:8535~8543 [34] 65 Yao B L,Wang Y L,Hu K S,Chen D L,Zheng Y,Lei M.Photochem Photobiol,2002,76(5):545~548 [35] 66 Tamogami J,Kikukawa T,Miyauchi S,Muneyuki E,Kamo N.Photochem Photobiol,2009,85:578~589 [36] 68 Wang J P,Yoo S K,Song L,El-Sayed M A.J Phys Chem B,1997,101:3420~3423 [37] 77 Garczarek F,Brown L S,Lanyi J K,Gerwert K.Proc Natl Acad Sci USA,2005,102:3633~3638 [38] 78 Zhao Y C,Wang Y Z,Ma D W,Wu J,Huang W D,Ding J D.Biosci Biotechnol Biochem,2011,75:1364~1370 [39] 81 Li H,Chen D L,Hu K S,Han B S.Chin Sci Bull,2003,48:573~576 [40] 82 Ming M,Wang Y Z,Wu J,Ma D W,Li Q G,Ding J D.FEBS Lett,2006,580:6749~6753 [41] 84 Kalmbach R,Chizhov I,Schumacher M C,Friedrich T,Bamberg E,Engelhard M.J Mol Biol,2007,371:639~648 [42] 85 Cladera J,Rigaud J L,Villaverde J,Dunach M.Eur J Biochem,1997,243:798~804 [43] 86 Freisleben H J,Zwicker K,Jezek P,John G,Bettin-Bogutzki A,Ring K,Nawroth T.Chem Phys Lipids,1995,78:137~147 [44] 94 Ding J D,Ming M,Ma D W,Huang W D,Hong J,Li Q G.Chinese patent,ZL200510028918.8.2008-06-18 [45] 95 Ding J D,Wu J.Chinese patent,ZL200710044244.X.2012-02-08 [46] 96 Zeisel D,Hampp N.J Phys Chem,1992,96:7788~7792 [47] 97 Liang B,Li B F,Zhang J P,Jiang L.New J Chem,2002,26:1049~1053 [48] 100 Ma D W,Zhao Y C,Wu J,Cui T,Ding J D.Soft Matter,2009,5:4635~4637 [49] 101 Ma Dewang(马德旺).Effects of synthetic polymers on functions of retinal proteins and related polymer/protein functional materials(合成高分子对视黄醛膜蛋白功能的影响及相应功能材料的研究).Doctoral Dissertation of Fudan University(复旦大学博士学位论文),2010 [50] 102 Lu Junjun(陆俊珺),Ming Ming(明明),Yang Yi(杨毅),Wu Jia(吴佳),Li Bo(李波),Ding Jiandong(丁建东),Li Qingguo(李庆国),Qian Shixiong(钱士雄).Acta Biochim Biophys Sin(生物化学与生物物理学报),2004,36(11):724~728 [51] 103 Ma Dewang(马德旺),Ming Ming(明明),Hong Jie(洪洁),Wu Jia(吴佳),Li Qingguo(李庆国),Huang Weida(黄伟达),Ding Jiandong(丁建东).Acta Polymerica Sinica(高分子学报),2006,(9):1078~1082 [52] 104 Wei L,Luo J,Zhu J,Lu M,Zhao Y Y,Ma D W,Ding J D.Appli Phys Lett,2007,90:173902-1-173902-3 [53] 105 Wei L,Teng X L,Lu M,Zhao Y Y,Ma D W,Ding J D.Chin Phys Lett,2007,24(12):3356~3359 [54] 106 Teng X L,Lu M,Zhao Y Y,Ma D W,Zhao Y C,Ding J D,Huang W D.Appl Phys Lett,2010,97:071109(071109-1~071109-3) [55] 108 Sun J G,Graeter S V,Yu L,Duan S F,Spatz J P,Ding J D.Biomacromolecules,2008,9:2569~2572 [56] 109 Sun J G,Tang J,Ding J D.Chin Sci Bull,2009,54:3154~3159 [57] 110 Lai Y X,Xie C,Zhang Z,Lu W Y,Ding J D.Biomaterials,2010,31:4809~4817 [58] 114 Chang G T,Li C,Lu W Y,Ding J D.Macromol Biosci,2010,10:1248~1256 [59] 116 Zhao Y C,Ding J D.Chin Sci Bull,2012,57:234~237 [60] 117 Chaumont A,Baer M,Mathias G,Marx D.ChemPhysChem,2008,9:2751~2758 [61] 118 Chen Y T,Zhang Q,Ding J D.J Chem Phys,2004,120:3467~3474 [62] 119 Cui T,Ding J D,Chen J Y.Macromolecules,2006,39:5540~5545 [63] 120 Lu W Q,Ding J D.Macromolecules,2006,39:7433~7440 [64] 123 Luo Z L,Ding J D,Zhou Y Q.Biophys J,2007,93:2152~2161 [65] 124 Chen Y T,Zhou Y Q,Ding J D.Proteins:Structure,Function,and Bioinformatics,2007,69:58~68 [66] 125 Luo Z L,Ding J D,Zhou Y Q.J Chem Phys,2008,128:225103(1-8) [67] 128 Chen Yantao(陈彦涛),Ding Jiandong(丁建东).Acta Polymerica Sinica(高分子学报),2010,(7):918~923 [68] 129 Huang J H,Grater S V,Corbellinl F,Rinck S,Bock E,Kemkemer R,Kessler H,Ding J D,Spatz J P.Nano Lett,2009,9:1111~1116 [69] 130 Tang J,Peng R,Ding J D.Biomaterials,2010,31:2470~2476 [70] 134 Pan Z,Yan C,Peng R,Zhao Y C,He Y,Ding J D.Biomaterials,2012,33:1730~1735 [71] 1 Xie Laiyong(谢来勇), Hong Fei(鸿飞),Liu Jianhong(刘剑洪),Zhang Guangzhao(张广照),Wu Chi(吴奇).Acta Polymerica Sinica(高分子学报),2011,(9):1020~1025 [72] 3 She Wenchuan(佘汶川),Luo kui(罗奎),He Bin(何斌),Ai Hua(艾华),Gu Zhongwei(顾忠伟).Acta Polymerica Sinica(高分子学报),2011,(2):157~165 [73] 6 Zhou G,Cheng Y X,Wang L X,Jing X B,Wang F S.Macromolecules,2005,38:2148~2153 [74] 7 Yang L G,Chen L,Bai R,Yang F,Wang M,Chen H Z.Solar Energy Materials & Solar cells,2007,91:1110~1119 [75] 8 Cao Y,Parker I D,Yu G,Zhang C,Heeger A J.Nature,397:414~417 [76] 9 Liu Lulin(柳露林),Song Wenli(宋文利),Zhang Zhiyong(张志勇),Sun Pengfei(孙鹏飞),Lu Xiaomei(卢晓梅),Fan Quli(范曲立),Huang Wei(黄维).Acta Polymerica Sinica(高分子学报),2011,(7):724~728 [77] 10 Zhao Ruiyang(赵瑞阳),Zhang Wensi(张文思),Ma Yuguang(马於光).Acta Polymerica Sinica(高分子学报),2011(9):985~1000 [78] 11 Lü Ang(吕昂),Zhang Lina(张俐娜).Acta Polymerica Sinica(高分子学报),2007,(10):937~944 [79] 12 Shi Xiaowen(施晓文),Li Xiaoxia(李晓霞),Du Yumin(杜予民).Acta Polymerica Sinica(高分子学报),2011,(1):1~11 [80] 14 Lanyi J K.Annu Rev Physiol,2004,66:665~688 [81] 16 Oesterhelt D,Stoeckenius W.Nat New Biol,1971,233:149~152 [82] 17 Khorana H G,Gerber G E,Herlihy W C,Gray C P,Anderegg R J,Nihei K,Biemann K.Proc Natl Acad Sci US,1979,76:5046~5050 [83] 19 Luecke H,Schobert B,Richter H T,Cartailler J P,Lanyi J K.J Mol Biol,1999,291:899~911 [84] 20 Balashov S P,Imasheva E S,Govindjee R,Ebrey T G.Biophys J,1996,70:473~481 [85] 21 Robertson B,Lukashev E P.Biophys J,1995,68:1507~1517 [86] 22 Joh N H,Min A,Faham S,Whitelegge J P,Yang D,Woods Jr V L,Bowie J U.Nature,2008,453(79):1266~1270 [87] 23 Prokhorenko V I,Nagy A M,Waschuk S A,Brown L S,Birge R R,Miller R J D.Science,2006,313(5791):1257~1261 [88] 25 Huang Yuhua(黄玉华),Zhao Youyuan(赵有源),Ouyang Xiaoping(欧阳晓平),Gong Qinggan(龚勤敢),Yang Qun(杨群),Cheng Linbing(陈凌冰),Li Fuming(李富铭),Zhang Zhongbin(张忠宾),Liujian(刘坚),Ding Jiandong(丁建东),Li Qingguo(李庆国).J Optoelectronics Laser(光电子激光),1999,10:37~39 [89] 31 Huang Y H,Zhao Y Y,Ouyang X P,Li F M,Ding J D,Li Q G.Chin Phys Lett,2003,20(6):959~961 [90] 33 Tian Y,Jiang L.Sci China Chem,2011,54:603~610 [91] 34 Hampp N.Chem Rev,2000,100:1755~1776 [92] 35 Chen Deliang(陈德亮),Hu Kunsheng(胡坤生).Acta Biophysica Sinica(生物物理学报),2001,17:441~448 [93] 39 Yao Baoli(姚保利),Li Baofang(李宝芳),Li Xingchang(李兴长).Prog Biochem.Biophys(生物化学与生物物理进展),2001,28:844~847 [94] 40 Zheng Yuan(郑媛),Yao Baoli(姚保利),Wang Yingli(王英利),Lei Ming(雷铭).Science in China-Series A(中国科学-A辑),2002,32:481~486 [95] 41 Mukohata Y,Sugiyama Y,Ihara K,Yoshida M.Biochem Biophys Res Commum,1988,151:1339~1345 [96] 42 Enami N,Yoshimura K,Murakami1 M,Okumura H,Ihara K,Kouyama T.J Mol Biol,2006,358:675~685 [97] 45 Li Q G.,Sun Q A,Zhao W,Wang H,Xu D Q.Biochim Biophys Acta-Biomembr,2000,1466:260~266 [98] 48 Wang Yiran(王奕然),Hong Jie(洪洁),Ming Ming(明明),Ding Jiandong(丁建东),Li Qingguo(李庆国),Huang Weida(黄伟达).J Fudan Univ(复旦大学学报),2003,42:576~583 [99] 53 Wada T, Shimono K,Kikukawa T,Hato M,Shinya N,Kim S Y,Kimura-Someya T,Shirouzu M,Tamogami J,Miyauchi S,Jung K H,Kamo N,Yokoyama S.J Mol Biol,2011,411:986~998 [100] 56 Kikukawa T,Shimono K,Tamogami J,Miyauchi S,Kim S Y,Kimura-Someya T,Shirouzu M,Jung K H,Yokoyama S,Kamo N.Biochemistry,2011,50:8888~8898 [101] 61 Henderson R,Unwin P N.Nature,1975,257:28~32 [102] 67 Robertson B,Lukashev E P.Biophys J,1995,68:1507~1517 [103] 69 Wang J P,Song L,Yoo S K,El-Sayed M A.J Phys Chem B,1997,101:10599~10604 [104] 70 Koyama K,Sumi M,Kamo N,Lanyi J K.Biochemistry and Bioenergetics,1998,46:289~292 [105] 71 Wu J,Ma D W,Wang Y Z,Ming M,Balashov S P,Ding J D.J Phys Chem B,2009,113:4482~4491 [106] 72 Iwamoto M,Shimono K,Sumi M,Koyama K,Kamo N J.Phys Chem B,1999,103:10311~10315 [107] 73 Chu L K,Yen C W,El-Sayed M A.Biosens Bioelectron,2010,26:620~626 [108] 74 Wang Y Z,Wu J,Ming M,Zhao Y C,Ding J D.Biosci Biotechnol Biochem,2012,76:250~256 [109] 75 Balashov S P.Biochimica et Biophysica Acta,2000,1460:75~94 [110] 76 Govindjee R,Imasheva E,Misra S,Balashov S P,Ebrey T G,Chen N,Menick D R,Crouch R K.Biophys J,1997,72(2):TU396~TU396 [111] 79 Zhao Yingchun(赵迎春).Effects of mutagenesis on functions of bacteriorhodopsin and corresponding protein-based functional materials(基因突变对细菌视紫红质功能的影响及相关功能材料研究).Doctoral Dissertation of Fudan University(复旦大学博士学位论文),2011 [112] 80 Wang Y Z,Zhao Y C,Ming M,Wu J,Huang W D,Ding J D.Photochem Photobiol,doi:10.1111/j.1751-1097.2012.01146.x [113] 83 Ollivon M,Lesieur S,Grabielle-Madelmont C,Paternostre M.Biochim Biophys Acta-Biomembr,2000,1508:34~50 [114] 87 Liu Jian(刘坚),Zhu Yue(朱悦),Li Qingguo(李庆国),Ding Jiandong(丁建东).J Fudan Univ(复旦大学学报),1999,38(5):549~552 [115] 88 Huang Li(黄力),Ming Ming(明明),Liu Jia(刘嘉),Liu Jian(刘坚),Li Qingguo(李庆国),Ding Jiandong(丁建东).Acta Biochimica et Biophysica Sinica(生物化学与生物物理学报),2003,35:391~395 [116] 89 Ming Ming(明明),Liu Jia(刘嘉),Huang Li(黄力),Liu Jian(刘坚),Li Qingguo(李庆国),Ding Jiandong(丁建东).J Funct Polym(功能高分子学报),2003,16(3):405~411 [117] 90 Liu Jia(刘嘉),Ming Ming(明明),Liu Jian(刘坚),Huang Li(黄力),Li Qingguo(李庆国),Ding Jiandong(丁建东).Acta Chimica Sinica(化学学报),2002,60(12):2209~2213 [118] 91 Weetall H H,Druzhko A B.Curr Appl Phys,2003,3(2-3):281~291 [119] 92 Korchemskaya E,Burykin N,de Lera A,Alvarez R,Pirutin S,Druzhko A.Photochem Photobiol,2005,81(4):920~923 [120] 93 Wang Y Z,Wu J,Ma D W,Ding J D.Sci China Chem,2011,54:405~409 [121] 98 Zhao Y C,Ming M,Hong J,Ma D W,Wu J,Li Q G,Huang W D,Ding J D.Chin Sci Bull,2010,55:3825~3830 [122] 99 Ma D W,Wang Y Z,Wu J,Zhao Y C,Ming M,Ding J D.Soft Matter,2010,6:4920~4930 [123] 107 Zhao Y C,Wu J,Huang W D,Ding J D.Chin J Chem,2012,30:491~495 [124] 111 Zhang Z,Lai Y X,Yu L,Ding J D.Biomaterials,2010,31:7873~7882 [125] 112 Huang J H,Ding J D.Soft Matter,2010,6:3395~3401 [126] 113 Liu P,Sun J G,Huang J H,Peng R,Tang J,Ding J D.Nanoscale,2010,2:122~127 [127] 115 Zhang Z,Ni J,Chen L,Yu L,Xu J W,Ding J D.Biomaterials,2011,32:4725~4736 [128] 121 Ji S C,Ding J D.Langmuir,2006,22:553~559 [129] 122 Chen Y T,Zhang Q,Ding J D.J Chem Phys,2006,124:184903(1-8) [130] 126 Cui T,Ding J D,Chen J Y.Phys Rev E,2008,78:061802(1-7) [131] 127 Chen Yantao(陈彦涛),Ding Jiandong(丁建东).Acta Polymerica Sinica(高分子学报),2009,(12):1238~1244 [132] 131 Liu P,Ding J D.Langmuir,2010,26:492~497 [133] 132 Yan C,Sun J G,Ding J D.Biomaterials,2011,32:3931~3938 [134] 133 Peng R,Yao X,Ding J D.Biomaterials,2011,32:8048~8057
Full-Text
Contact Us
service@oalib.com
QQ:3279437679
WhatsApp +8615387084133
