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OALib Journal期刊
ISSN: 2333-9721
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表面接枝嵌段共聚物刷实现内皮细胞的选择性黏附
DOI: 10.3724/SP.J.1105.2013.13017, PP. 1108-1114
Keywords: 聚(甲基丙烯酸寡聚乙二醇酯),聚(甲基丙烯酸缩水甘油酯),GREDVY,内皮细胞,选择性黏附
Abstract:
利用表面引发原子转移自由基聚合(SI-ATRP)技术将聚(甲基丙烯酸寡聚乙二醇酯)和聚(甲基丙烯酸缩水甘油酯)的双嵌段共聚物刷(POEGMA-b-PGMA)接枝在材料表面,并通过PGMA中丰富的环氧基团开环固定可特异性黏附内皮细胞的多肽GREDVY.静态水接触角、接枝层厚度、X射线光电子能谱(XPS)以及原子力显微镜(AFM)的测试结果证明了各步接枝反应的成功性.细胞培养研究表明这种连接有GREDVY的双嵌段共聚物表面能够有效的促进血管内皮细胞的黏附,同时排斥成纤维细胞的黏附,从而实现了内皮细胞的选择性黏附.
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