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靶向MPO的磁性纳米粒子的制备与表征

DOI: 10.11777/j.issn1000-3304.2015.14295, PP. 331-337

Keywords: 磁性氧化铁纳米粒子,髓过氧化物酶,5-羟色胺,靶向核磁造影剂

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Abstract:

将表面含有大量氨基的树枝状分子聚酰胺-胺与油溶性的氧化铁纳米粒子(IONPs)进行配体交换,制备了水溶性氧化铁纳米粒子,将动脉粥样硬化斑块中髓过氧化物酶(MPO)的靶向分子5-羟色胺(5-HT)接枝到以树枝状分子为载体的体系上,最后得到树枝状分子包覆IONPs纳米粒子-g-PEG-g-5-羟色胺(5-HT-PEG-G3.0@IONPs),可以作为一种靶向动脉粥样硬化斑块的核磁造影成像剂.通过测试产物的红外光谱(FTIR),证明合成了5-HT-PEG-G3.0@IONPs纳米粒子.TEM测试结果表明该纳米粒子的的粒径约为10nm左右,DLS测试结果显示的粒径约为31.0nm.利用5-HT具有紫外特征吸收峰(276nm),确定了终产物中5-HT的接枝量为6.19μg/mg.TGA结果表明5-HT-PEG-G3.0@IONPs的氧化铁含量为2wt%.VSM测试结果表明该产物具有超顺磁性,且饱和磁化强度为1.47A·m2/kg.

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