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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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侧基为磺酸根基团的聚丁二酸丁二醇酯共聚物的合成及应用研究
DOI: 10.11777/j.issn1000-3304.2015.14260, PP. 298-305
Keywords: 聚(丁二酸丁二醇酯-共-富马酸丁二醇酯),磺化,自组装,纳米胶束,药物释放
Abstract:
以丁二酸,富马酸和1,4-丁二醇为原料,通过溶液聚合的方法合成了一系列主链含有碳碳双键的不饱和脂肪族聚酯,聚(丁二酸丁二醇酯-共-富马酸丁二醇酯)P(BS-co-BF)s.以过量的NaHSO3为磺化试剂,合成了侧基为磺酸根基团的聚丁二酸丁二醇酯PBS共聚物P(BS-co-SBS)s.运用核磁共振氢谱(1H-NMR),红外光谱(IR)和凝胶渗透色谱(GPC)表征了共聚物的化学结构及分子量.结合溶剂挥发和透析法研究了系列共聚物P(BS-co-SBS)s在水中的自组装行为.动态光散射(DLS)和透射电镜(TEM)的研究发现,系列共聚物P(BS-co-SBS)s均可自组装形成稳定的、具有核壳结构,表面带有负电荷的胶束(尺寸103~165nm,PDI0.187~0.264,zeta电位-35~-51mV).载药和释药的结果显示,胶束对疏水药物阿霉素具有一定的缓释效果.
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