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OALib Journal期刊
ISSN: 2333-9721
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超分子水凝胶作为胰岛素缓释体系的研究
DOI: 10.11777/j.issn1000-3304.2015.14395, PP. 673-678
Keywords: 环糊精,嵌段聚合物,聚乙二醇,超分子水凝胶,胰岛素
Abstract:
利用α-环糊精(α-CD)与含有聚乙二醇(PEG)链段的聚合物PluronicF127的超分子作用制备水凝胶.该物理交联水凝胶的交联点包括α-CD与PEG链包合物堆积形成的微晶区和聚合物疏水链段聚集区.优化水凝胶组分,得到具有较低固含量和较短凝胶化时间的体系用于胰岛素的负载和释放研究.通过X射线衍射(XRD),扫描显微镜(SEM)对水凝胶结构进行表征.通过紫外分光光度计监测胰岛素的释放过程,结果表明,水凝胶释药时间约为65h,且释放曲线较为平缓.细胞毒性实验结果表明该水凝胶材料对细胞生长无明显抑制作用.小鼠体内释药实验结果表明该水凝胶载体对延长胰岛素的释药时间有一定效果,可作为多肽类药物的缓释体系.
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