|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
pH敏感两亲性嵌段共聚物胶束的制备及其负载紫杉醇体外药效的研究
DOI: 10.11777/j.issn1000-3304.2015.15031, PP. 1100-1106
Keywords: 两亲性嵌段共聚物,胶束,pH敏感性,紫杉醇,细胞毒性
Abstract:
采用可逆加成-断裂链转移(RAFT)聚合法,以丙烯酸(AA)、丙烯酸异丁酯(IBA)无规共聚物与聚丙烯酸-2-羟丙酯(PHPA)反应,制备了具有pH敏感性的两亲性嵌段共聚物(P(IBA-co-AA)-b-PHPA).用红外光谱(FTIR)、核磁共振(1H-NMR)、凝胶渗透色谱(GPC)对其结构进行表征.此共聚物在水溶液中可自组装形成胶束,临界胶束浓度约为2.0mg/L.由透射电子显微镜(TEM)、动态光散射(DLS)表征可知胶束为尺寸约100nm的球形颗粒;用DLS观察到胶束粒径随pH值的升高而逐渐增大.以抗癌药物紫杉醇为模型药物,研究载药胶束在模拟人体环境中的控释行为.用CellCountingKit-8(简称CCK-8)法分别研究聚合物胶束对MCF-7人乳腺癌细胞和A549人肺癌细胞的细胞毒性,并评价载药胶束在两细胞中的抗癌效果.结果表明,P(IBA-co-AA)-b-PHPA可作为包载紫杉醇的一种新型纳米材料,载药胶束的体外释放呈明显pH依赖性,且具有较好的体外抗肿瘤活性,有望成为理想的抗肿瘤药物载体.
| [1] | 1 Li S L, Palmer A F.Macromolecules,2005,38(13):5686~5698
|
| [2] | 2 Geng Y,Ahmed F,Bhasin N,Discher D E.J Phys Chem B,2005,109(9):3772~3779
|
| [3] | 3 Ouarti N,Vivile P,Lazzaroni R,Minatti E,Schappacher M,Deffieux A,Borsali R.Langmuir,2005,24(4):1180~1186
|
| [4] | 4 Zou Peng(邹鹏),Pan Caiyuan(潘才元).Acta Polymerica Sinica(高分子学报),2007,(10):974~978
|
| [5] | 5 Wei H,Cheng S X,Zhang X Z,Zhuo R X.Prog Polym Sci,2009,34(9):893~910
|
| [6] | 6 Zheng Xiaoming(郑晓明),Jiang Tao(蒋涛),He Feng(贺枫).Acta Polymerica Sinica(高分子学报),2011,(8):895~902
|
| [7] | 10 Zhang K,Wu X Y.Biomateirals,2004,25(22):5281~5291
|
| [8] | 18 Chong Y K,Krstina J.Macromolecules,2003,36(7):2256~2272
|
| [9] | 19 Wei H,Zhang X Z,Cheng C,Cheng S X,Zhuo R X.Biomaterials,2007,28(1):99~107
|
| [10] | 20 Luo Y L,Yao X J,Yuan J F,Ding T,Gao Q Y.Colloids Surf,B.2009,68(2):218~224
|
| [11] | 21 Soppimath K S,Tan D C W,Yang Y Y.Adv Mater,2005,17(3):318~323
|
| [12] | 22 Gao W W,Chan J M,Farokhzad O C.Mol Pharmaceutics,2010,7(6):1913~1920
|
| [13] | 23 Liu J,Zhang C,Ping Q N.Sciencepaper Online,2011,9(6):649~655
|
| [14] | 24 Chuan X X,Song Q,Lin J L,Chen X H,Zhang H,Dai W B,He B,Wang X Q,Zhang Q.Mol Pharmaceutics,2014,11(10):3656~3670
|
| [15] | 25 Du L,Andrew J.Robles,Jarrod B.King,Susan L.Mooberry,Robert H.Cichewicz.J Nat Prod,2014,77(6):1459~1466
|
| [16] | 7 Liu Qing(刘青),Hong Chunyan(洪春雁),Pan Caiyuan(潘才元).Acta Polymerica Sinica(高分子学报),2015,(1):15~24
|
| [17] | 8 Manchun S,Dass C R,Sriamomsak P.Life Sci,2012,90(11-12):381~387
|
| [18] | 9 Guo Li(郭莉),Jing Huanwang(景欢旺).Materials Review(材料导报),2012,(12):70~76
|
| [19] | 11 He C L,Zhao C W,Guo Z J,Chen X S,Zhuang X L,Liu S Y,Jing X B.J Polym Sci,Part A:Polym Chem,2008,46(12):4140~4150
|
| [20] | 12 Luo H X,Pi M S,Mei S P.Journal of Qiqihar Medical College,2006,27(13):1570
|
| [21] | 13 Hiramatsu H P,Kikuchi Y,Seto H,Nagata I.Anti-Cancer Drugs,2000,11(7):573~578
|
| [22] | 14 Li Shufeng(李蜀凤),Liu Daxing(刘大兴),Zheng Yonghui(郑勇辉),Yue Ying(岳瑛),Huang Yubin(黄宇彬),Jing Xiabin(景遐斌).Acta Polymerica Sinica(高分子学报),2012,(9):1029~1034
|
| [23] | 15 Vo C D,Rosselgone J,Armes P.J Polym Sci Part A:Polym Chem,2010,18:2032~2043
|
| [24] | 16 Liu Y H,Sun J,Cao W,Yang J H,Lian H,Li X,Sun Y H,Wang Y J,Wang S L,He Z G.Int J Pharm,2011,421(1):160~169
|
| [25] | 17 Davies M C,Dawkins J V,Hourston D J.Polymer,2005,46(6):1739~1753
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
