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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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基于酒石酸衍生物的聚合物型手性固定相的制备及手性识别
DOI: 10.11777/j.issn1000-3304.2015.15035, PP. 1107-1113
Keywords: 酒石酸衍生物,合成高分子,手性固定相,手性识别
Abstract:
以D-(-)-酒石酸和D-(-)-酒石酸二异丙基酯为手性源,合成了D-(-)-酒石酸二苄酯和D-(-)-酒石酸二苄胺,这2种单体再分别与对苯二甲酰氯和对苯二异氰酸酯进行聚合,得到聚酯和聚氨酯型手性选择体.将这2种聚合物同时键合到氨丙基硅胶上制得双选择体手性固定相.为了比较分离性能,将两种聚合物分别单独地键合在氨丙基硅胶上,制备了2种单选择体手性固定相.用FTIR、元素分析和NMR对所合成的化合物进行了表征.在相同色谱条件下,用31种手性化合物对3种固定相的手性识别能力进行了评价.研究结果表明,3种固定相均具有较好的手性识别能力,双选择体固定相手性识别能力优于单选择体手性固定相,双选择体手性固定相中的2个选择体之间存在协同作用.
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