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低结晶度聚ε-己内酯电纺膜的制备及其药物控释行为

DOI: 10.3724/SP.J.1105.2011.11020, PP. 446-451

Keywords: 稀土催化剂,ε-己内酯,无规共聚,静电纺丝,水杨酸,药物释放

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Abstract:

以芳氧基稀土三(2,6-二叔丁基-4-甲基苯氧基)镧(La(OAr)3)为催化剂,通过加入少量(8.5mol%)碳酸2,2-二甲基三亚甲基酯(DTC)与ε-己内酯(CL)进行无规共聚合,成功制备了低结晶度的脂肪族内酯-碳酸酯无规共聚酯(PCD)材料,并用1H-NMR、SEC、DSC和WAXS证明了产物的结构和性能.以聚ε己内酯(PCL)和PCD为基质、以水杨酸为模型药物,通过静电纺丝的方法制备了载药量为8wt%、直径为1μm的电纺纤维膜,并测试了其体外药物释放行为.结果表明,PCD电纺纤维膜显示了可控的药物缓释行为而PCL电纺纤维则呈现了药物暴释的现象.DSC和WAXS分析表明,这两个体系药物释放行为的差异是由基质结晶度的差别产生的.PCD电纺膜的结晶度(χc=40.3%)远远低于PCL电纺膜(χc=79.3%),且晶区也更加不完善,药物能更多更好地融合在非晶区中,并通过高分子链的热运动缓慢释放.

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