|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
单模微波辐照下壳聚糖-左旋聚乳酸接枝共聚物的酶催化合成
DOI: 10.3724/SP.J.1105.2012.11287, PP. 593-598
Keywords: 接枝聚合,酶催化,微波,壳聚糖,左旋聚乳酸
Abstract:
以猪胰脂肪酶(PPL)代替传统的有机金属作为催化剂,在单模微波辐照下利用左旋丙交酯(L-LA)的开环聚合制备壳聚糖-左旋聚乳酸(CS-g-PLLA)接枝共聚物.考察了反应温度及酶用量对接枝率的影响.以此为基础,利用DTG、XRD和3T3成纤维细胞培养对产物的物理性能及细胞相容性进行分析.结果显示,猪胰酶可有效催化接枝反应的进行.反应温度和酶用量对产物的接枝率有较大影响.在单模微波作用下,较低的反应温度(50℃)可获得具有较高接枝率(178.8%)的接枝产物.与纯壳聚糖相比,接枝产物的结晶度和热稳定性降低,说明PLLA的引入破坏了壳聚糖的高结晶性.产物具有良好的细胞相容性,可作为优良的组织工程支架材料.
| [1] | 6 Li L H,Zhou C R,Ding S.J Appl Polym Sci,2004,91:274~277.
|
| [2] | 9 Uyama H,Kobayashi S.Chem Lett,1993,7:1149~1150
|
| [3] | 10 Fujioka M,Okada H,Kusaka Y,Nishiyama S,Noguchi H,Ishii S,Yoshida Y.Macromol Rapid Commun,2004,25:1776~1780
|
| [4] | 11 Ge H C,Pang W,Luo D K.Carbohydr Polym,2006,66:372~378
|
| [5] | 12 Singh V,Tiwari A,Tripathi D N,Sanghi R.Polymer,2006,47:254~260
|
| [6] | 13 Varma I K,Albertsson A C,Rajkhowa R,Srivastava R K.Prog Polym Sci,2005,30:949~981
|
| [7] | 18 Yuan Hua(袁华),Ge Fangfang(葛芳芳),Qiao Xinle(乔馨乐),Ren Jie(任杰).Polymer Materials Science and Engineering(高分子材料科学与工程),2009,25:1~4
|
| [8] | 19 Howling G I,Dettmar P W,Goddard P A,Hampson F C,Dornish M,Wood E J.Biomaterials,2001,22:2959~2966
|
| [9] | 20 Mao J S,Cui Y L,Wang X H,Sun Y,Yin Y J,Zhao H M,Yao K D.Biomaterials,2004,25:3973~3981
|
| [10] | 1 Shi Xiaowen(施晓文), Li Xiaoxia(李晓霞),Du Yumin(杜予民).Acta Polymerica Sinica(高分子学报),2011,(1):1~11
|
| [11] | 2 Martino A D,Sittinger M,Risbud M V.Biomaterials,2005,26:5983~5990
|
| [12] | 3 Zhang L,Ao Q,Wang A J,Lu G G,Kong L J,Gong Y D,Zhao N M,Zhang X F.J Biomed Mater Res Part A,2007,77A:277~284
|
| [13] | 4 Yao F G,Chen W,Wang H,Liu H F,Yao K D,Sun P C,Lin H.Polymer,2003,44:6435~6441
|
| [14] | 5 Luckachan G E,Pillai C.K.S.Carbohydr Polym,2006,64:254~266.
|
| [15] | 7 Wang J L,Wang,L,Dong C M.J Polym Sci Part A:Polym Chem,2005,43:5449~5457
|
| [16] | 8 Zhu Hao(朱浩),Hou Chen(侯晨),Li Yanfeng(李彦锋).Acta Polymerica Sinica(高分子学报),2011,(8):861~865
|
| [17] | 14 Ariela V P,Daniele U,Julio C S,Heizir F D Castro.J Chem Technol Biotechnol,2007,82:281~288
|
| [18] | 15 Witzke D R,Narayan R.Macromolecules,1997,30:7075~7085
|
| [19] | 16 Wirsen X Q A,Albertsson A C.Polymer,2000,41:4841~4847
|
| [20] | 17 Kulkarni R K,Moore E G,Hegyeli A F,Leonard F.J Biomed Mater Res,1971,5:169~181
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
