OALib Journal期刊
磁性热敏聚合物微球的制备及磁感应控制释放行为
DOI: 10.3724/SP.J.1105.2012.11370
Keywords: 热敏 ,聚合物微球 ,磁感应 ,控制释放
Abstract:
采用种子乳液聚合法在Fe3O4纳米粒子表面聚合包覆N-异丙基丙烯酰胺(NIPAM)与α-甲基丙烯酸(MAA)的共聚物,制备了磁性热敏聚合物微球Fe3O4/P(NIPAM-co-MAA).利用广角X射线衍射仪(WAXD)、透射电子显微镜(TEM)、zeta粒度仪(DLS)、热重分析(TGA)、振动样品磁力计(VSM)及比表面积测试仪(BET)等对微球的结构与形貌进行了表征,通过紫外-可见光分光光度法(UV-Vis)研究了微球对水溶性模型药物罗丹明B(RhB)的负载和磁感应控制释放行为.结果表明,微球粒径为80~200nm,比表面积约为30.04m2/g,平均孔径约为24.50nm;微球中聚合物含量约为73wt%,磁粒子含量约为20wt%,饱和磁感应强度为16.49emu/g,其体积相转变温度(VPTT)约为37.5℃.RhB在微球中的装载量可以达到16.38mg/g;在外加交变磁场作用下,RhB在模拟肠液和胃液中的磁感应释放量分别达到10.47和13.02mg/g.
References
[1] 1 Guo M,Yan Y, Zhang H K,Yan H S,Cao Y J,Liu K L,Wan S R,Huang J S,Yue W.J Mater Chem,2008,18:5104~5112 [2] 2 Wu Chenlin(武承林),He Huan(贺欢),Gao Hongjun(高红军),Liu Gan(刘赣),Ma Rujiang(马如江),An Yingli(安英丽),Shi Linqi(史林启).Scienia Sinica Chimica(中国科学:化学),2010,40(3):269~275 [3] 7 Lu Y,Mei Y,Drechsler M,Ballauff M.Angew Chem Int Ed,2006,45(5):813~816 [4] 9 Gong Tao(龚涛),Wang Changchun(汪长春).Acta Polymerica Sinica(高分子学报),2008,(11):1037~1042 [5] 17 Li Xiaodong(李晓东),Shen Jiacong(沈家骢).Chemical Journal of Chinese Universities(高等学校化学学报),2007,28(10):2000~2005 [6] 18 Detlef M S,Thomas S R.J Magn Magn Mater,2006,302:267~271 [7] 3 Zheng Xiaoming(郑晓明),Jiang Tao(蒋涛),He Feng(贺枫).Acta Polymerica Sinica(高分子学报),2011,(8):895~902 [8] 4 Chen L B,Zhang F,Wang C C.Small,2009,5(5):621~628 [9] 5 Wu Huidan(吴慧丹),Qian Hao(钱浩),Yu Zhijun(余智军),Ye Wenhu(叶文虎).Acta Polymerica Sinica(高分子学报),2010,(10):1238~1244 [10] 6 Adelsberger J,Kulkarni A,Jain A,Wang W N,Bivigou K A M,Busch P,Pipic V,Holderer O,Hellweg T,Laschewsky A,Müller B P,Papadakis C M.Macromolecules,2010,43:2490~2501 [11] 8 Chen T Y,Cao Z,Guo X L,Nie J J,Xu J T,Fan Z Q,Du B Y.Polymer,2011,52(1):172~179 [12] 10 Deng Y H,Yang W L,Wang C C,Fu S K.Adv Mater,2003,15(20):1729~1732 [13] 11 Kim D J,Kang S M,Kong B,Kim W J,Paik H J,Choi H,Choi I S.Macromol Chem Phys,2005,206(16):1941~1946 [14] 12 Xu Yawen(徐雅雯),Xu Hong(徐宏),Ding Weijie(丁玮洁),Gu Hongchen(古宏晨).Acta Polymerica Sinica(高分子学报),2010,(11):1340~1345 [15] 13 Dimitrov I,Trzebicka B,Müller A H E,Dworak A,Tsvetanov C B.Prog Polym Sci,2007,32(11):1275~1343 [16] 14 Rong Jianhua(容建华),Duan Taiwei(段泰炜),Wen Hongge(温鸿戈),Qu Xiaozhong(屈小中).Acta Polymerica Sinica(高分子学报),2010,(4):484~489 [17] 15 Kono K.Adv Drug Delivery Rev,2007,32(11):1275~1343 [18] 16 Lu Jing(陆晶),Huang Li(黄丽),Shao Chunlei(邵春雷),Dong Wenbo(董文博),Hou Huiqi(侯惠奇).Environmental Chemistry(环境化学),2007,26(3):366~370
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