OALib Journal期刊
接枝微球CPVA-g-PSSS的制备及其对5-氟尿嘧啶载药及体外结肠定位释药特性研究
DOI: 10.3724/SP.J.1105.2012.12003
Keywords: 对苯乙烯磺酸钠 ,交联聚乙烯醇微球 ,接枝聚合 ,5-氟尿嘧啶 ,pH依赖性 ,结肠定位释放
Abstract:
在具有生物相容性的交联聚乙烯醇(CPVA)微球表面,采用铈盐-羟基氧化还原引发体系,实施了对苯乙烯磺酸钠(SSS)的表面引发接枝聚合,制得了接枝有聚阴离子的接枝微球CPVA-g-PSSS,采用红外光谱(FTIR)、扫描电子显微镜(SEM)及zeta电位测定等法,对接枝微球的化学结构及物理化学特性进行了表征.在此基础上重点考察分析了接枝微球CPVA-g-PSSS对5-氟尿嘧啶(5-FU)的吸附(载药)性能与吸附机理,考察探索了载药微球在不同pH介质中的释放行为.实验结果表明,羟基-铈盐氧化还原引发体系可有效地引发SSS在CPVA微球的表面接枝聚合,在适宜的反应条件下,可制得PSSS接枝度为16.1g/100g的接枝微球CPVA-g-PSSS.在酸性介质中,受强静电相互作用的驱动,接枝微球CPVA-g-PSSS对5-FU分子表现出很强的吸附能力,吸附容量达105mg/g,可实现有效载药.载药微球的释药行为具有强烈的pH依赖性,在pH=1的介质中,基本不释药;而在pH=7.4的介质中,则发生突释,表现出良好的结肠定位释放行为.
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