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聚富马酸丙二醇酯/羟基磷灰石复合多孔水凝胶的制备及其矿化性能研究

DOI: 10.3724/SP.J.1105.2012.12129, PP. 1143-1150

Keywords: 聚富马酸羟丙酯,纳米羟基磷灰石,多孔水凝胶,矿化

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Abstract:

采用二步法合成了可降解的聚富马酸丙二醇酯(poly(propylenefumarate),PPF),并和N-乙烯基吡咯烷酮(N-vinylpyrrolidone,NVP)共聚,以1,4-二氧六环为溶剂,通过改变溶剂的量制备了溶胀性能不同的PPF水凝胶.采用万能力学测试仪和扫描电子显微镜分别表征了水凝胶的压缩模量和形貌结构.选择20%PPF和10%NVP的聚合体系,预掺3%的纳米羟基磷灰石(hydroxyapatite,HA),以氯化钠粒子为致孔剂,制备了孔径在280~450μm的纳米复合多孔水凝胶,使其压缩模量提高了61%.模拟体液矿化10天的结果显示,磷灰石成核位点的存在和良好的与外界液体环境物质交换的能力,促进了多孔水凝胶表面磷灰石的沉积,说明HA的复合可以有效提高PPF多孔水凝胶的成骨活性.

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