|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
聚己二酸丁二酯纳米纤维构建的微球的制备
DOI: 10.3724/SP.J.1105.2013.13043, PP. 781-787
Keywords: 聚合物微球,纳米纤维,异相成核,酶促水解
Abstract:
建立了采用异相成核和可控水解相结合的方法制备由纳米纤维构建的聚合物微球的新方法.根据多取代卞叉山梨醇(TM6)对聚己二酸丁二酯(PBA)的异相成核作用以及结晶形态的影响,采用两种乳液溶剂挥发法、并在聚合物溶液中加入成核剂TM6制备了PBA微球,研究了成核剂含量对PBA微球在酶促降解之后形态变化的影响.研究结果表明,二次乳液溶剂挥发法可以制备具有多孔结构的PBA微球,这种多孔结构有利于酶溶液进入到微球内部,促进PBA微球的均匀水解,最终获得由PBA纳米纤维构建的微球.当TM6的含量为3wt%时,采用二次乳液溶剂挥发法制备的PBA微球,经过5h酶促降解处理,可以得到表面和内部由PBA纳米纤维均匀组成的微球.进一步的细胞实验表明,微球的纳米纤维结构,有利于MG-63细胞在聚合物微球上的黏附、铺展和向内生长.
| [1] | 10 Shi Xudong(石旭东),Zhang Yu(张玉),Yu Guoqiang(于国强),Gan Zhihua(甘志华).Acta Polymerica Sinica(高分子学报),2012,(10):1157~1163
|
| [2] | 1 Langer R, Vacanti J P.Science,1993,260:920~926
|
| [3] | 2 Tian Zhi(田冶),Wang Yingjun(王迎军),Zhou Changren(周长忍),Zeng Qinghui(曾庆慧),Tan Guoxin(谭帼馨).Acta Polymerica Sinica(高分子学报),2010,(10):1170~1174
|
| [4] | 3 Chen Da(陈达),Chen Jian(计剑),Shen Jiacong(沈家骢).Acta Polymerica Sinica(高分子学报),2004,(6):826~830
|
| [5] | 4 Pachence J M,Kohn J.In Principles of Tissue Engineering.San Diego:Academic Press,1997.273~293
|
| [6] | 5 Liu X H,Holzwarth J M,Ma P X.Macromol Bios,2012,12:911~919
|
| [7] | 6 Finne-Wistrand A,Albertsson A C,Kwon O H,Kawazoe N,Chen G,Kang I K,Hasuda H,Gong J,Ito Y.Macromol Bios,2008,8:951~959
|
| [8] | 7 Bailey B M,Fei R C,Munoz-Pinto Dany,Hahn M S,Grunlan M A.Acta Biomater,2012,8:4324~4333
|
| [9] | 8 Chen J L,Chu B,Hsiao B S.J Biomed Mater Res Part A,2006,79A:307~317
|
| [10] | 9 Malda J,Frondoza C G.Trends in Biotechnology,2006,24:299~304
|
| [11] | 11 Shi X D,Jiang J,Zhang X,Ding W J,Gan Z H.Macromol Bios,2009,9:1211~1218
|
| [12] | 12 Zhang Y,Sun L,Jiang J,Zhang X,Ding W J,Gan Z H.Polym Degrad Stab,2010,95:1356~1364
|
| [13] | 13 Yu G,Zhang Y,Shi X,Li Z,Gan Z.J Biomed Mater Res Part A,2008,84A:926~939
|
| [14] | 14 Yu Guoqiang(于国强),Shi Xudong(石旭东),Gan Zhihua(甘志华).Acta Polymerica Sinica(高分子学报),2006,(5):740~744
|
| [15] | 15 Shi X D,Jiang J,Sun L,Gan Z H.Colloids and Surfaces B:Biointerfaces,2011,85:73~80
|
| [16] | 16 Jiang N,Zhao L F,Gan Z H.Polym Degrad Stab,2010,95:1045~1053
|
| [17] | 17 Gan Z H,Abe H,Doi Y.Macromol Chem Phys,2002,203:2369~2674
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
