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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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可降解聚乙交酯-丙交酯缓释微球用于甲状旁腺相关肽的持续释放
DOI: 10.3724/SP.J.1105.2014.13213, PP. 270-275
Keywords: 甲状旁腺相关肽,聚乙交酯-丙交酯,微球,控制释放
Abstract:
采用水包油包水（W1/O/W2）复乳溶剂挥发法制备了包载甲状旁腺激素相关肽（PTHrP）的聚乙交酯-丙交酯（PLGA）微球，通过核磁，红外，GPC，扫描电子显微镜等观察PLGA载药微球的结构，表明载药微球具有良好的球形结构，其平均粒径约为8μm.而体外模拟释放表明，此PLGA载药微球能实现PTHrP1-34长达25天的持续释放.并通过MTT法、碱性磷酸酶活性测定等检测负载PTHrP1-34的PLGA微球缓释系统对小鼠成骨细胞MC3T3-E1增殖及分化的影响，结果表明PTHrP1-34浓度为1×10-9mol/L时对MC3T3-E1增殖促进效应最大，且随着药物作用时间的延长，缓释系统促进细胞增殖、分化的作用越明显.
| [1] | 9 Jiang G, Matsumoto H, FujⅡ A.J Dent Res, 2007, 86:52~57
|
| [2] | 10 Yang J, Farnell D, Devlin H.J Dent Res, 2005, 33:123~129
|
| [3] | 17 Shi Xudong(石旭东), Sun Lei(孙磊), Gan Zhihua(甘志华).Acta Polymerica Sinica(高分子学报), 2011, (8):866~873
|
| [4] | 18 Zhang Xiumei(张秀梅), Cai Jing(蔡静), Yang Yanan(杨亚楠), Chen Xuesi(陈学思), Xie Xuming(谢续明).Acta Polymerica Sinica(高分子学报), 2011, (6):653~660
|
| [5] | 19 Alves E C, Szejnfeld V L, Pereira S N, Coelho L E, Heldan M C.Calcif Tissue Int, 2010, 87(5):424~436
|
| [6] | 1 Canalis E. Clinical Endocrinology & Metabolism, 2010, 95(4):1496~1506
|
| [7] | 2 Blind E.Clinical Laboratory, 2008, 54(11):439~449
|
| [8] | 3 Pleiner D J, Zwettler E, Paschalis E.Calcified Tissue International, 2009, 84(3):159~170
|
| [9] | 4 Chen C, Koh A J, Datta N S.J Biol Chem, 2004, 279:29121~29129
|
| [10] | 5 Devogelaer J P, Boutsen Y, Manicourt D H.Current Osteoporosis Report, 2010, 8(3):154~161
|
| [11] | 6 Inoue D, Matsumoto T.Biomed Pharma-cother, 2000, 54:32s~41s
|
| [12] | 7 Horwitz M J, Tedesco M B, Gundberg C.J Clin Endocrinol Metab, 2003, 88:569~575
|
| [13] | 8 Stewrat A F, Cain R L, Burr D B.J Bone Miner Res, 2000, 15(8):1517~1525
|
| [14] | 11 Li Cong(李聪), Zhang Zhe(张喆), He Chaoliang(贺超良), Zhuang Xiuli(庄秀丽), Chen Li(陈莉), Cai Qing(蔡青), Xue Yan(薛妍), Zhang Bin(张宾), Wang Shizhen(王世振), Meng Weiyan(孟维艳), Chen Xuesi(陈学思).Acta Polymerica Sinica(高分子学报), 2012, (7):778~783
|
| [15] | 12 Vahle J L, Sato M, Long G.Toxicol Pathol, 2002, 30(3):312~321
|
| [16] | 13 Cann C, Oe E, Sanchez S, Arnaud C.J Bone Miner Res, 2000, 66(6):456~460
|
| [17] | 14 Lu Rong(陆荣), Zhang Feng(张峰), Ding Cuicui(丁翠翠), Li Suya(李苏亚).Technology & Development of Chemical Industry(化工技术与开发), 2010, 39(9):4~7
|
| [18] | 15 Jung R E, Cochran D L, Domken O, Seibl R, Jones A A, Buser D, Hammerle C H.Clin Oral Implants Res, 2007, 18(3):319~325
|
| [19] | 16 Xiong Lei(熊雷), Jiang Hongwei(姜宏伟), Wang Dizhen(王迪珍).Acta Polymerica Sinica(高分子学报), 2008, (8):791~796
|
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