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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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含磺胺嘧啶基团的葡聚糖钆配合物的研究
DOI: 10.3724/SP.J.1105.2014.13288, PP. 263-269
Keywords: 磁共振成像,造影剂,肿瘤靶向,葡聚糖,磺胺嘧啶,细胞摄取,二乙三胺五乙酸
Abstract:
将具有肿瘤靶向性的磺胺嘧啶（SD）、二乙三胺五乙酸（DTPA）与葡聚糖（dextran）大分子侧链羟基偶联，合成葡聚糖大分子配体（SD-Dextran-DTPA），再与金属钆离子Gd3+配合，从而制备肿瘤靶向性葡聚糖大分子钆配合物（SD-Dextran-DTPA-Gd）.对所合成的配体及钆配合物进行FTIR、UV和1H-NMR等结构表征，测试了配体及钆配合物在水溶液中的粒径分布和zeta电位、钆配合物的体外弛豫率、细胞摄取与T1加权磁共振成像性能.与小分子钆-二乙三胺五乙酸（Gd-DTPA）相比，SD-Dextran-DTPA-Gd具有较高的弛豫率，对肺癌细胞系H460、乳腺癌细胞系MDA-MB-231和T40D均有较好的亲和性，可被肿瘤细胞较好地摄取，并能获得较好的肿瘤细胞磁共振成像.
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