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OALib Journal期刊
ISSN: 2333-9721
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聚己内酯-聚铵盐抗菌材料的制备
DOI: 10.3724/SP.J.1105.2014.13364, PP. 782-788
Keywords: 聚己内酯,聚季铵盐,嵌段聚合物,抗菌材料
Abstract:
通过开环聚合（ROP）和原子转移自由基聚合（ATRP）制备了一类聚己内酯-聚阳离子酯嵌段共聚物（LPCL-b-PJDMA）.聚合物的制备通过四步反应合成（1）月桂醇引发开环引发ε-己内酯合成LPCL；（2）以2-溴异丁酰溴（BIBB）封端LPCL制备大分子引发剂；（3）用氯乙酸甲酯对甲基丙烯酸二甲氨基乙酯（DMA）进行季铵化反应制备阳离子小分子（命名为JDMA）；（4）用五甲基二乙基三胺（PMDETA）/溴化亚铜为催化剂，催化不同链段数的LPCL与JDMA发生ATRP反应制得LPCL-b-PJDMA.通过核磁氢谱（1H-NMR）对聚合物的化学结构进行表征，确认合成目标产物.利用示差扫描量热仪（DSC）对其热性进行研究，并用水接触角的方法测量聚合物膜亲水性，最后通过测试细菌在聚合物膜上的存活率的方法测定其抗菌性能.结果表明，LPCL与PJDMA共聚后，随着PCL重复单元数增加，共聚物结晶温度相对于纯PCL出现明显的先降低后升高趋势.LPCL-b-PJDMA的亲水性都比纯PCL好，且与LPCL/PJDMA的比例有关.所有的LPCL-b-PJDMA膜对革兰氏阴性菌和革兰氏阳性菌都具有抗菌能力.
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